α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
α-Synuclein-specific T cell reactivity is preferentially associated with Parkinson’s disease (PD) patients, but the temporal relation with diagnosis was previously unknown. This study reveals that α-syn-reactive T cells are highest before and shortly after diagnosis of motor PD, and then decrease....
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15626-w |
| _version_ | 1818683016626569216 |
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| author | Cecilia S. Lindestam Arlehamn Rekha Dhanwani John Pham Rebecca Kuan April Frazier Juliana Rezende Dutra Elizabeth Phillips Simon Mallal Mario Roederer Karen S. Marder Amy W. Amara David G. Standaert Jennifer G. Goldman Irene Litvan Bjoern Peters David Sulzer Alessandro Sette |
| author_facet | Cecilia S. Lindestam Arlehamn Rekha Dhanwani John Pham Rebecca Kuan April Frazier Juliana Rezende Dutra Elizabeth Phillips Simon Mallal Mario Roederer Karen S. Marder Amy W. Amara David G. Standaert Jennifer G. Goldman Irene Litvan Bjoern Peters David Sulzer Alessandro Sette |
| author_sort | Cecilia S. Lindestam Arlehamn |
| collection | DOAJ |
| description | α-Synuclein-specific T cell reactivity is preferentially associated with Parkinson’s disease (PD) patients, but the temporal relation with diagnosis was previously unknown. This study reveals that α-syn-reactive T cells are highest before and shortly after diagnosis of motor PD, and then decrease. |
| first_indexed | 2024-12-17T10:28:02Z |
| format | Article |
| id | doaj.art-9731c07b2438479d8928e5d35c33b9a6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:28:02Z |
| publishDate | 2020-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9731c07b2438479d8928e5d35c33b9a62022-12-21T21:52:36ZengNature PortfolioNature Communications2041-17232020-04-0111111110.1038/s41467-020-15626-wα-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s diseaseCecilia S. Lindestam Arlehamn0Rekha Dhanwani1John Pham2Rebecca Kuan3April Frazier4Juliana Rezende Dutra5Elizabeth Phillips6Simon Mallal7Mario Roederer8Karen S. Marder9Amy W. Amara10David G. Standaert11Jennifer G. Goldman12Irene Litvan13Bjoern Peters14David Sulzer15Alessandro Sette16Division of Vaccine Discovery, La Jolla Institute for ImmunologyDivision of Vaccine Discovery, La Jolla Institute for ImmunologyDivision of Vaccine Discovery, La Jolla Institute for ImmunologyDivision of Vaccine Discovery, La Jolla Institute for ImmunologyDivision of Vaccine Discovery, La Jolla Institute for ImmunologyDepartment of Neurology, Columbia University Medical CenterVanderbilt University School of MedicineVanderbilt University School of MedicineVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Neurology, Columbia University Medical CenterDepartment of Neurology, University of Alabama at BirminghamDepartment of Neurology, University of Alabama at BirminghamShirley Ryan AbilityLab, Northwestern University Feinberg School of MedicineDepartment of Neurology, University of California San DiegoDivision of Vaccine Discovery, La Jolla Institute for ImmunologyDepartment of Neurology, Columbia UniversityDivision of Vaccine Discovery, La Jolla Institute for Immunologyα-Synuclein-specific T cell reactivity is preferentially associated with Parkinson’s disease (PD) patients, but the temporal relation with diagnosis was previously unknown. This study reveals that α-syn-reactive T cells are highest before and shortly after diagnosis of motor PD, and then decrease.https://doi.org/10.1038/s41467-020-15626-w |
| spellingShingle | Cecilia S. Lindestam Arlehamn Rekha Dhanwani John Pham Rebecca Kuan April Frazier Juliana Rezende Dutra Elizabeth Phillips Simon Mallal Mario Roederer Karen S. Marder Amy W. Amara David G. Standaert Jennifer G. Goldman Irene Litvan Bjoern Peters David Sulzer Alessandro Sette α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease Nature Communications |
| title | α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease |
| title_full | α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease |
| title_fullStr | α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease |
| title_full_unstemmed | α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease |
| title_short | α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease |
| title_sort | α synuclein specific t cell reactivity is associated with preclinical and early parkinson s disease |
| url | https://doi.org/10.1038/s41467-020-15626-w |
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