The Role of Genistein in Mammalian Reproduction
Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen. As such, genistein can bind estrogen receptors (ERα and ERβ), although with a lower affinity than that of estradiol. Despite consid...
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MDPI AG
2023-11-01
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| author | Gabriella Guelfi Rolando Pasquariello Polina Anipchenko Camilla Capaccia Georgia Pennarossa Tiziana A. L. Brevini Fulvio Gandolfi Massimo Zerani Margherita Maranesi |
| author_facet | Gabriella Guelfi Rolando Pasquariello Polina Anipchenko Camilla Capaccia Georgia Pennarossa Tiziana A. L. Brevini Fulvio Gandolfi Massimo Zerani Margherita Maranesi |
| author_sort | Gabriella Guelfi |
| collection | DOAJ |
| description | Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen. As such, genistein can bind estrogen receptors (ERα and ERβ), although with a lower affinity than that of estradiol. Despite considerable work, the effects of genistein are not well established yet. This review aims to clarify the role of genistein on female and male reproductive functions in mammals. In females, at a high dose, genistein diminishes the ovarian activity regulating several pathway molecules, such as topoisomerase isoform I and II, protein tyrosine kinases (v-src, Mek-4, ABL, PKC, Syk, EGFR, FGFR), ABC, CFTR, Glut1, Glut4, 5α-reductase, PPAR-γ, mitogen-activated protein kinase A, protein histidine kinase, and recently circulating RNA-miRNA. The effect of genistein on pregnancy is still controversial. In males, genistein exerts an estrogenic effect by inducing testosterone biosynthesis. The interaction of genistein with both natural and synthetic endocrine disruptors has a negative effect on testis function. The positive effect of genistein on sperm quality is still in debate. In conclusion, genistein has a potentially beneficial effect on the mechanisms regulating the reproduction of females and males. However, this is dependent on the dose, the species, the route, and the time of administration. |
| first_indexed | 2024-03-11T11:24:29Z |
| format | Article |
| id | doaj.art-97358df94e904d1c8fac14423877e13f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T11:24:29Z |
| publishDate | 2023-11-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-97358df94e904d1c8fac14423877e13f2023-11-10T15:08:59ZengMDPI AGMolecules1420-30492023-11-012821743610.3390/molecules28217436The Role of Genistein in Mammalian ReproductionGabriella Guelfi0Rolando Pasquariello1Polina Anipchenko2Camilla Capaccia3Georgia Pennarossa4Tiziana A. L. Brevini5Fulvio Gandolfi6Massimo Zerani7Margherita Maranesi8Department of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyDepartment of Agricultural and Environmental Sciences, University of Milan, 20133 Milano, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyDepartment of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, ItalyDepartment of Agricultural and Environmental Sciences, University of Milan, 20133 Milano, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, ItalyGenistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen. As such, genistein can bind estrogen receptors (ERα and ERβ), although with a lower affinity than that of estradiol. Despite considerable work, the effects of genistein are not well established yet. This review aims to clarify the role of genistein on female and male reproductive functions in mammals. In females, at a high dose, genistein diminishes the ovarian activity regulating several pathway molecules, such as topoisomerase isoform I and II, protein tyrosine kinases (v-src, Mek-4, ABL, PKC, Syk, EGFR, FGFR), ABC, CFTR, Glut1, Glut4, 5α-reductase, PPAR-γ, mitogen-activated protein kinase A, protein histidine kinase, and recently circulating RNA-miRNA. The effect of genistein on pregnancy is still controversial. In males, genistein exerts an estrogenic effect by inducing testosterone biosynthesis. The interaction of genistein with both natural and synthetic endocrine disruptors has a negative effect on testis function. The positive effect of genistein on sperm quality is still in debate. In conclusion, genistein has a potentially beneficial effect on the mechanisms regulating the reproduction of females and males. However, this is dependent on the dose, the species, the route, and the time of administration.https://www.mdpi.com/1420-3049/28/21/7436polyphenolsflavonoidsisoflavonesgenisteinphytoestrogensovary |
| spellingShingle | Gabriella Guelfi Rolando Pasquariello Polina Anipchenko Camilla Capaccia Georgia Pennarossa Tiziana A. L. Brevini Fulvio Gandolfi Massimo Zerani Margherita Maranesi The Role of Genistein in Mammalian Reproduction Molecules polyphenols flavonoids isoflavones genistein phytoestrogens ovary |
| title | The Role of Genistein in Mammalian Reproduction |
| title_full | The Role of Genistein in Mammalian Reproduction |
| title_fullStr | The Role of Genistein in Mammalian Reproduction |
| title_full_unstemmed | The Role of Genistein in Mammalian Reproduction |
| title_short | The Role of Genistein in Mammalian Reproduction |
| title_sort | role of genistein in mammalian reproduction |
| topic | polyphenols flavonoids isoflavones genistein phytoestrogens ovary |
| url | https://www.mdpi.com/1420-3049/28/21/7436 |
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