Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates
The role of tissue mechanics in the regeneration of mucociliated epithelium in Xenopus is unclear. Here, the authors show that Xenopus ectoderm aggregates undergo epithelial-like phenotypic transition prior to differentiation of mucus-secreting goblet cells to enable regeneration.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14385-y |
| _version_ | 1819129354891821056 |
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| author | Hye Young Kim Timothy R. Jackson Carsten Stuckenholz Lance A. Davidson |
| author_facet | Hye Young Kim Timothy R. Jackson Carsten Stuckenholz Lance A. Davidson |
| author_sort | Hye Young Kim |
| collection | DOAJ |
| description | The role of tissue mechanics in the regeneration of mucociliated epithelium in Xenopus is unclear. Here, the authors show that Xenopus ectoderm aggregates undergo epithelial-like phenotypic transition prior to differentiation of mucus-secreting goblet cells to enable regeneration. |
| first_indexed | 2024-12-22T08:42:23Z |
| format | Article |
| id | doaj.art-973608bc2abf45929471f292816a4fd9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:42:23Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-973608bc2abf45929471f292816a4fd92022-12-21T18:32:12ZengNature PortfolioNature Communications2041-17232020-01-0111111010.1038/s41467-020-14385-yTissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregatesHye Young Kim0Timothy R. Jackson1Carsten Stuckenholz2Lance A. Davidson3Department of Bioengineering, Swanson School of Engineering, University of PittsburghDepartment of Bioengineering, Swanson School of Engineering, University of PittsburghDepartment of Bioengineering, Swanson School of Engineering, University of PittsburghDepartment of Bioengineering, Swanson School of Engineering, University of PittsburghThe role of tissue mechanics in the regeneration of mucociliated epithelium in Xenopus is unclear. Here, the authors show that Xenopus ectoderm aggregates undergo epithelial-like phenotypic transition prior to differentiation of mucus-secreting goblet cells to enable regeneration.https://doi.org/10.1038/s41467-020-14385-y |
| spellingShingle | Hye Young Kim Timothy R. Jackson Carsten Stuckenholz Lance A. Davidson Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates Nature Communications |
| title | Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates |
| title_full | Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates |
| title_fullStr | Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates |
| title_full_unstemmed | Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates |
| title_short | Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates |
| title_sort | tissue mechanics drives regeneration of a mucociliated epidermis on the surface of xenopus embryonic aggregates |
| url | https://doi.org/10.1038/s41467-020-14385-y |
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