Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells

Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells

Our recent study detected the expression of a tissue renin–angiotensin system (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of the angiotensin II receptor type 1 (AGTR1) antagonist losartan on human nucleus pulposus (NP) cell inflammation and degener...

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Bibliographic Details
Main Authors: Babak Saravi, Zhen Li, Judith Pfannkuche, Laura Wystrach, Sonja Häckel, Christoph E. Albers, Sibylle Grad, Mauro Alini, Robert Geoffrey Richards, Corinna Lang, Norbert Südkamp, Hagen Schmal, Gernot Lang
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Applied Sciences
Subjects:
intervertebral disc
renin–angiotensin system
degeneration
regeneration
spine
inflammation
Online Access:https://www.mdpi.com/2076-3417/11/1/417

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