Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression
Introduction:: Electroconvulsive therapy (ECT) is a highly efficient treatment for depression. Previous studies repeatedly reported an ECT-induced volume increase in the hippocampi. We assume that this also affects extended hippocampal networks. This study aims to investigate the structural and func...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223000931 |
| _version_ | 1797803939856384000 |
|---|---|
| author | Niklaus Denier Sebastian Walther Sigrid Breit Nicolas Mertse Andrea Federspiel Agnes Meyer Leila M. Soravia Meret Wallimann Roland Wiest Tobias Bracht |
| author_facet | Niklaus Denier Sebastian Walther Sigrid Breit Nicolas Mertse Andrea Federspiel Agnes Meyer Leila M. Soravia Meret Wallimann Roland Wiest Tobias Bracht |
| author_sort | Niklaus Denier |
| collection | DOAJ |
| description | Introduction:: Electroconvulsive therapy (ECT) is a highly efficient treatment for depression. Previous studies repeatedly reported an ECT-induced volume increase in the hippocampi. We assume that this also affects extended hippocampal networks. This study aims to investigate the structural and functional interplay between hippocampi, hippocampal pathways and core regions of the default mode network (DMN). Twenty patients with a current depressive episode receiving ECT-treatment and twenty age and sex matched healthy controls (HC) were included in the study. ECT-patients underwent multimodal magnetic resonance imaging (MRI)-scans (diffusion weighted imaging, resting state functional MRI) before and after an ECT-index series. HC were also scanned twice in a similar between-scan time-interval. Parahippocampal cingulum (PHC) and uncinate fasciculus (UF) were reconstructed for each participant using manual tractography. Fractional anisotropy (FA) was averaged across tracts. Furthermore, we investigated seed-based functional connectivity (FC) from bilateral hippocampi and from the PCC, a core region of the DMN. At baseline, FA in PHC and UF did not differ between groups. There was no baseline group difference of hippocampal-FC. PCC-FC was decreased in ECT-patients. ECT induced a decrease in FA in the left PHC in the ECT group. No longitudinal changes of FA were found in the UF. Furthermore, there was a decrease in hippocampal-PCC-FC, an increase in hippocampal-supplementary motor area-FC, and an increase in PCC-FC in the ECT-group, reversing group differences at baseline. Our findings suggest that ECT induces structural and functional remodeling of a hippocampal-DMN. Those changes may contribute to ECT-induced clinical response in patients with depression. |
| first_indexed | 2024-03-13T05:28:35Z |
| format | Article |
| id | doaj.art-97372d20f6d94e1dbb7a13fa073697da |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-03-13T05:28:35Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-97372d20f6d94e1dbb7a13fa073697da2023-06-15T04:55:52ZengElsevierNeuroImage: Clinical2213-15822023-01-0138103404Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depressionNiklaus Denier0Sebastian Walther1Sigrid Breit2Nicolas Mertse3Andrea Federspiel4Agnes Meyer5Leila M. Soravia6Meret Wallimann7Roland Wiest8Tobias Bracht9Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland; Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland; Corresponding author at: University Hospital of Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland.Introduction:: Electroconvulsive therapy (ECT) is a highly efficient treatment for depression. Previous studies repeatedly reported an ECT-induced volume increase in the hippocampi. We assume that this also affects extended hippocampal networks. This study aims to investigate the structural and functional interplay between hippocampi, hippocampal pathways and core regions of the default mode network (DMN). Twenty patients with a current depressive episode receiving ECT-treatment and twenty age and sex matched healthy controls (HC) were included in the study. ECT-patients underwent multimodal magnetic resonance imaging (MRI)-scans (diffusion weighted imaging, resting state functional MRI) before and after an ECT-index series. HC were also scanned twice in a similar between-scan time-interval. Parahippocampal cingulum (PHC) and uncinate fasciculus (UF) were reconstructed for each participant using manual tractography. Fractional anisotropy (FA) was averaged across tracts. Furthermore, we investigated seed-based functional connectivity (FC) from bilateral hippocampi and from the PCC, a core region of the DMN. At baseline, FA in PHC and UF did not differ between groups. There was no baseline group difference of hippocampal-FC. PCC-FC was decreased in ECT-patients. ECT induced a decrease in FA in the left PHC in the ECT group. No longitudinal changes of FA were found in the UF. Furthermore, there was a decrease in hippocampal-PCC-FC, an increase in hippocampal-supplementary motor area-FC, and an increase in PCC-FC in the ECT-group, reversing group differences at baseline. Our findings suggest that ECT induces structural and functional remodeling of a hippocampal-DMN. Those changes may contribute to ECT-induced clinical response in patients with depression.http://www.sciencedirect.com/science/article/pii/S2213158223000931ECTWhite matterResting state functional connectivityHippocampusUncinate fasciculus, parahippocampal cingulum, posterior cingulate cortex |
| spellingShingle | Niklaus Denier Sebastian Walther Sigrid Breit Nicolas Mertse Andrea Federspiel Agnes Meyer Leila M. Soravia Meret Wallimann Roland Wiest Tobias Bracht Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression NeuroImage: Clinical ECT White matter Resting state functional connectivity Hippocampus Uncinate fasciculus, parahippocampal cingulum, posterior cingulate cortex |
| title | Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression |
| title_full | Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression |
| title_fullStr | Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression |
| title_full_unstemmed | Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression |
| title_short | Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression |
| title_sort | electroconvulsive therapy induces remodeling of hippocampal co activation with the default mode network in patients with depression |
| topic | ECT White matter Resting state functional connectivity Hippocampus Uncinate fasciculus, parahippocampal cingulum, posterior cingulate cortex |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223000931 |
| work_keys_str_mv | AT niklausdenier electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT sebastianwalther electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT sigridbreit electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT nicolasmertse electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT andreafederspiel electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT agnesmeyer electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT leilamsoravia electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT meretwallimann electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT rolandwiest electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression AT tobiasbracht electroconvulsivetherapyinducesremodelingofhippocampalcoactivationwiththedefaultmodenetworkinpatientswithdepression |