Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients
Introduction: Dexmedetomidine is an alpha-2 agonist used for conscious sedation. It has also been shown to have a myocardial protective effect in off-pump coronary artery bypass patients. The aim of the study was to assess the effect of dexmedetomidine for myocardial protection in percutaneous coron...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Annals of Cardiac Anaesthesia |
| Subjects: | |
| Online Access: | http://www.annals.in/article.asp?issn=0971-9784;year=2016;volume=19;issue=3;spage=394;epage=398;aulast=Kundra |
| _version_ | 1818196816702734336 |
|---|---|
| author | Tanveer Singh Kundra P S Nagaraja Naveen G Singh Manasa Dhananjaya N Sathish N Manjunatha |
| author_facet | Tanveer Singh Kundra P S Nagaraja Naveen G Singh Manasa Dhananjaya N Sathish N Manjunatha |
| author_sort | Tanveer Singh Kundra |
| collection | DOAJ |
| description | Introduction: Dexmedetomidine is an alpha-2 agonist used for conscious sedation. It has also been shown to have a myocardial protective effect in off-pump coronary artery bypass patients. The aim of the study was to assess the effect of dexmedetomidine for myocardial protection in percutaneous coronary interventional patients. Methodology: A total of 60 patients (group dexmedetomidine, n = 30 and group normal saline, n = 30) were enrolled in the study. Dexmedetomidine infusion (1 mcg/kg) over 15 min was given as a loading dose after coronary angiography in group dexmedetomidine (D) while normal saline was given in the control group (C) and later maintenance infusion was started at 0.5 mcg/kg/h in both the groups. Coronary vessel diameter was noted before (T0) and after (T1) loading dose of dexmedetomidine/saline in each group. Troponin T (Trop T) values were noted at baseline (T0), 6 h (T2), 12 h (T3) and 24 h (T4) after starting the loading dose. Hemodynamic variables (heart rate [HR] and blood pressure) were monitored at T0, T1, and at regular intervals till 2 h postprocedure. Results: Coronary vessel diameter and HR significantly decreased in group D as compared to control group (P < 0.05) whereas the decrease in Trop T at 6 h, 12 h, and 24 h were not statistically significant between the two groups. Conclusion: Dexmedetomidine decreases the coronary vessel diameter, but maintains the myocardial oxygen demand-supply ratio by decreasing the HR. The decrease in Trop T is statistically insignificant at the doses used. |
| first_indexed | 2024-12-12T01:40:06Z |
| format | Article |
| id | doaj.art-9737412b1c0e4badae332710ae4f5554 |
| institution | Directory Open Access Journal |
| issn | 0971-9784 |
| language | English |
| last_indexed | 2024-12-12T01:40:06Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Cardiac Anaesthesia |
| spelling | doaj.art-9737412b1c0e4badae332710ae4f55542022-12-22T00:42:44ZengWolters Kluwer Medknow PublicationsAnnals of Cardiac Anaesthesia0971-97842016-01-0119339439810.4103/0971-9784.185517Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patientsTanveer Singh KundraP S NagarajaNaveen G SinghManasa DhananjayaN SathishN ManjunathaIntroduction: Dexmedetomidine is an alpha-2 agonist used for conscious sedation. It has also been shown to have a myocardial protective effect in off-pump coronary artery bypass patients. The aim of the study was to assess the effect of dexmedetomidine for myocardial protection in percutaneous coronary interventional patients. Methodology: A total of 60 patients (group dexmedetomidine, n = 30 and group normal saline, n = 30) were enrolled in the study. Dexmedetomidine infusion (1 mcg/kg) over 15 min was given as a loading dose after coronary angiography in group dexmedetomidine (D) while normal saline was given in the control group (C) and later maintenance infusion was started at 0.5 mcg/kg/h in both the groups. Coronary vessel diameter was noted before (T0) and after (T1) loading dose of dexmedetomidine/saline in each group. Troponin T (Trop T) values were noted at baseline (T0), 6 h (T2), 12 h (T3) and 24 h (T4) after starting the loading dose. Hemodynamic variables (heart rate [HR] and blood pressure) were monitored at T0, T1, and at regular intervals till 2 h postprocedure. Results: Coronary vessel diameter and HR significantly decreased in group D as compared to control group (P < 0.05) whereas the decrease in Trop T at 6 h, 12 h, and 24 h were not statistically significant between the two groups. Conclusion: Dexmedetomidine decreases the coronary vessel diameter, but maintains the myocardial oxygen demand-supply ratio by decreasing the HR. The decrease in Trop T is statistically insignificant at the doses used.http://www.annals.in/article.asp?issn=0971-9784;year=2016;volume=19;issue=3;spage=394;epage=398;aulast=KundraDexmedetomidine; Percutaneous coronary intervention; Troponin |
| spellingShingle | Tanveer Singh Kundra P S Nagaraja Naveen G Singh Manasa Dhananjaya N Sathish N Manjunatha Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients Annals of Cardiac Anaesthesia Dexmedetomidine; Percutaneous coronary intervention; Troponin |
| title | Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients |
| title_full | Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients |
| title_fullStr | Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients |
| title_full_unstemmed | Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients |
| title_short | Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients |
| title_sort | effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients |
| topic | Dexmedetomidine; Percutaneous coronary intervention; Troponin |
| url | http://www.annals.in/article.asp?issn=0971-9784;year=2016;volume=19;issue=3;spage=394;epage=398;aulast=Kundra |
| work_keys_str_mv | AT tanveersinghkundra effectofdexmedetomidineondiseasedcoronaryvesseldiameterandmyocardialprotectioninpercutaneouscoronaryinterventionalpatients AT psnagaraja effectofdexmedetomidineondiseasedcoronaryvesseldiameterandmyocardialprotectioninpercutaneouscoronaryinterventionalpatients AT naveengsingh effectofdexmedetomidineondiseasedcoronaryvesseldiameterandmyocardialprotectioninpercutaneouscoronaryinterventionalpatients AT manasadhananjaya effectofdexmedetomidineondiseasedcoronaryvesseldiameterandmyocardialprotectioninpercutaneouscoronaryinterventionalpatients AT nsathish effectofdexmedetomidineondiseasedcoronaryvesseldiameterandmyocardialprotectioninpercutaneouscoronaryinterventionalpatients AT nmanjunatha effectofdexmedetomidineondiseasedcoronaryvesseldiameterandmyocardialprotectioninpercutaneouscoronaryinterventionalpatients |