Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways

Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways

Abstract Background Immunotargets including checkpoint inhibitors and toll-like receptor 8 agonists have recently gained attention for the recovery of hepatitis B virus (HBV)-specific T cell exhaustion in chronic hepatitis B(CHB). Chemokine receptors have a similar significant role during viral infe...

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Bibliographic Details
Main Authors: Arshi Khanam, Alip Ghosh, Joel V. Chua, Shyam Kottilil
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Translational Medicine
Subjects:
CHB
CCR4
CD4 and CD8 T cells
Tregs
Online Access:https://doi.org/10.1186/s12967-023-04104-8

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