Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study
BackgroundFor detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance...
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2018.00102/full |
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| author | Hye Shin Ahn Dong Wook Kim Yoo Jin Lee Chang Yoon Lee Ji-hoon Kim Yoon Jung Choi Song Lee Inseon Ryoo Jung Yin Huh Jin Yong Sung Jin Young Kwak Hye Jin Baek |
| author_facet | Hye Shin Ahn Dong Wook Kim Yoo Jin Lee Chang Yoon Lee Ji-hoon Kim Yoon Jung Choi Song Lee Inseon Ryoo Jung Yin Huh Jin Yong Sung Jin Young Kwak Hye Jin Baek |
| author_sort | Hye Shin Ahn |
| collection | DOAJ |
| description | BackgroundFor detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor recurrence in patients who had undergone thyroid surgery due to MTC.MethodsA total of 86 patients who had undergone thyroid surgery for the treatment of MTC and had at least one postoperative US follow-up examination at any of nine affiliated hospitals were included. Postoperative follow-up US, clinical, and histopathological results of patients were reviewed. The tumor recurrence/persistence rate of MTC was investigated, and the interval and session number of postoperative follow-up US and clinicopathologic factors were compared between tumor recurrence/persistence and non-recurrence groups.ResultsOf the 86 patients, 22 (25.6%) showed tumor recurrence/persistence. Of the 22 patients with tumor recurrence/persistence, 11 (50%) showed structural recurrence/persistence in the neck on follow-up US. In these 11 patients, the mean interval and session number of postoperative follow-up US between initial surgery and the first US detection of recurrence/persistence was 41.3 ± 39.3 months (range, 6–128 months) and 2.6 ± 2.3 (range, 1–8), respectively. On follow-up US, 6 (54.5%, 6/11) were diagnosed with tumor recurrence/persistence within 3 years of the initial surgery. Tumor recurrence/persistence was significantly correlated with TNM stage (p < 0.001) and multiplicity/bilaterality (p = 0.013).ConclusionFor detecting MTC recurrence/persistence, postoperative US surveillance at 1-year intervals may be sufficient within the first 3 years after thyroid surgery, but depending on the presence of relevant risk factors, annual or biannual US surveillance may be recommendable for 4–10 years after thyroid surgery. |
| first_indexed | 2024-12-10T20:58:51Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T20:58:51Z |
| publishDate | 2018-03-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-9739ae035e1f4e0b949e0538296aaaaa2022-12-22T01:33:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-03-01910.3389/fendo.2018.00102345599Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter StudyHye Shin Ahn0Dong Wook Kim1Yoo Jin Lee2Chang Yoon Lee3Ji-hoon Kim4Yoon Jung Choi5Song Lee6Inseon Ryoo7Jung Yin Huh8Jin Yong Sung9Jin Young Kwak10Hye Jin Baek11Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, South KoreaDepartment of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, South KoreaDepartment of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, South KoreaDepartment of Radiology, Research Institute and Hospital, National Cancer Center, Gyeonggi, South KoreaDepartment of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Radiology, Chak Han Madi Hospital, Incheon, South KoreaDepartment of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South KoreaDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South KoreaDepartment of Radiology, Thyroid Center, Daerim St. Mary’s Hospital, Seoul, South Korea0Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea1Department of Radiology, Gyeongsang National University School of Medicine, Gyeongsang National University Changwon Hospital, Changwon, South KoreaBackgroundFor detecting tumor recurrence of medullary thyroid carcinoma (MTC) in the neck, an appropriate frequency and interval of postoperative ultrasonography (US) surveillance remains unclear. This study aimed to assess an appropriate interval and frequency of postoperative neck US surveillance for detecting tumor recurrence in patients who had undergone thyroid surgery due to MTC.MethodsA total of 86 patients who had undergone thyroid surgery for the treatment of MTC and had at least one postoperative US follow-up examination at any of nine affiliated hospitals were included. Postoperative follow-up US, clinical, and histopathological results of patients were reviewed. The tumor recurrence/persistence rate of MTC was investigated, and the interval and session number of postoperative follow-up US and clinicopathologic factors were compared between tumor recurrence/persistence and non-recurrence groups.ResultsOf the 86 patients, 22 (25.6%) showed tumor recurrence/persistence. Of the 22 patients with tumor recurrence/persistence, 11 (50%) showed structural recurrence/persistence in the neck on follow-up US. In these 11 patients, the mean interval and session number of postoperative follow-up US between initial surgery and the first US detection of recurrence/persistence was 41.3 ± 39.3 months (range, 6–128 months) and 2.6 ± 2.3 (range, 1–8), respectively. On follow-up US, 6 (54.5%, 6/11) were diagnosed with tumor recurrence/persistence within 3 years of the initial surgery. Tumor recurrence/persistence was significantly correlated with TNM stage (p < 0.001) and multiplicity/bilaterality (p = 0.013).ConclusionFor detecting MTC recurrence/persistence, postoperative US surveillance at 1-year intervals may be sufficient within the first 3 years after thyroid surgery, but depending on the presence of relevant risk factors, annual or biannual US surveillance may be recommendable for 4–10 years after thyroid surgery.http://journal.frontiersin.org/article/10.3389/fendo.2018.00102/fullthyroidmalignancymedullary thyroid carcinomaultrasonographyrecurrencesurveillance |
| spellingShingle | Hye Shin Ahn Dong Wook Kim Yoo Jin Lee Chang Yoon Lee Ji-hoon Kim Yoon Jung Choi Song Lee Inseon Ryoo Jung Yin Huh Jin Yong Sung Jin Young Kwak Hye Jin Baek Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study Frontiers in Endocrinology thyroid malignancy medullary thyroid carcinoma ultrasonography recurrence surveillance |
| title | Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study |
| title_full | Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study |
| title_fullStr | Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study |
| title_full_unstemmed | Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study |
| title_short | Postoperative Neck Ultrasonography Surveillance After Thyroidectomy in Patients With Medullary Thyroid Carcinoma: A Multicenter Study |
| title_sort | postoperative neck ultrasonography surveillance after thyroidectomy in patients with medullary thyroid carcinoma a multicenter study |
| topic | thyroid malignancy medullary thyroid carcinoma ultrasonography recurrence surveillance |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2018.00102/full |
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