Structural disruption of Ntox15 nuclease effector domains by immunity proteins protects against type VI secretion system intoxication in Bacteroidales

Structural disruption of Ntox15 nuclease effector domains by immunity proteins protects against type VI secretion system intoxication in Bacteroidales

ABSTRACT Bacteroidales use type VI secretion systems (T6SS) to competitively colonize and persist in the colon. We identify a horizontally transferred T6SS with Ntox15 family nuclease effector (Tde1) that mediates interbacterial antagonism among Bacteroidales, including several derived from a single...

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Bibliographic Details
Main Authors: Dustin E. Bosch, Romina Abbasian, Bishal Parajuli, S. Brook Peterson, Joseph D. Mougous
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
microbiome
Bacteroides
type VI secretion system
inflammatory bowel disease
structural biology
Online Access:https://journals.asm.org/doi/10.1128/mbio.01039-23

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