Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series
Abstract This report covers the case of 7 women affected by pathologies related to genital Herpesvirus and Papillomavirus. They were referred to the gynaecology outpatient clinic for colposcopic examination, and received pharmacological antiviral treatment. The patients presented clinical signs of g...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13027-023-00511-0 |
| _version_ | 1797811975388921856 |
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| author | Maria Balestrieri Caterina Carnovale-Scalzo Anna Rosa Garbuglia Maria Vincenza Chiantore Luisa Accardi Paola Di Bonito |
| author_facet | Maria Balestrieri Caterina Carnovale-Scalzo Anna Rosa Garbuglia Maria Vincenza Chiantore Luisa Accardi Paola Di Bonito |
| author_sort | Maria Balestrieri |
| collection | DOAJ |
| description | Abstract This report covers the case of 7 women affected by pathologies related to genital Herpesvirus and Papillomavirus. They were referred to the gynaecology outpatient clinic for colposcopic examination, and received pharmacological antiviral treatment. The patients presented clinical signs of genital Herpesvirus infections in the cervix and vulva. Cervical lesions and condylomatosis, which are characteristic of Papillomavirus infections were also detected, and patients underwent cervical cancer screening. Patients received oral and topical treatment with Acyclovir or oral treatment with Valacyclovir. During weekly or biweekly gynaecological follow-up visits, patients showed different times of remission of genital Herpesvirus. During the antiviral treatments, the vulvar and cervical Papillomavirus lesions also showed complete resolution with restitutio ad integrum of the tissues, and no recurrence at follow-up visits. Herpesvirus and Papillomavirus infections are often associated in genital infections and, as sexual transmitted infections, share the same risk factors. In the cases presented, the observed remission of HPV-related pathologies during Acyclovir and Valaciclovir treatments may suggest that antivirals are also effective in the treatment of HPV lesions. The cases described could pave the way for further investigations and clinical studies. |
| first_indexed | 2024-03-13T07:30:44Z |
| format | Article |
| id | doaj.art-973bb628a8494ac583b1aa420595d5e5 |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-03-13T07:30:44Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-973bb628a8494ac583b1aa420595d5e52023-06-04T11:06:56ZengBMCInfectious Agents and Cancer1750-93782023-06-011811410.1186/s13027-023-00511-0Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case seriesMaria Balestrieri0Caterina Carnovale-Scalzo1Anna Rosa Garbuglia2Maria Vincenza Chiantore3Luisa Accardi4Paola Di Bonito5Gynaecology and Diagnostic Colposcopy ClinicHistopathology Laboratory, Ospedale San Carlo di Nancy, GVM Care and ResearchLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCSDepartment of Infectious Diseases, EVOR Unit, Istituto Superiore di SanitàDepartment of Infectious Diseases, EVOR Unit, Istituto Superiore di SanitàDepartment of Infectious Diseases, EVOR Unit, Istituto Superiore di SanitàAbstract This report covers the case of 7 women affected by pathologies related to genital Herpesvirus and Papillomavirus. They were referred to the gynaecology outpatient clinic for colposcopic examination, and received pharmacological antiviral treatment. The patients presented clinical signs of genital Herpesvirus infections in the cervix and vulva. Cervical lesions and condylomatosis, which are characteristic of Papillomavirus infections were also detected, and patients underwent cervical cancer screening. Patients received oral and topical treatment with Acyclovir or oral treatment with Valacyclovir. During weekly or biweekly gynaecological follow-up visits, patients showed different times of remission of genital Herpesvirus. During the antiviral treatments, the vulvar and cervical Papillomavirus lesions also showed complete resolution with restitutio ad integrum of the tissues, and no recurrence at follow-up visits. Herpesvirus and Papillomavirus infections are often associated in genital infections and, as sexual transmitted infections, share the same risk factors. In the cases presented, the observed remission of HPV-related pathologies during Acyclovir and Valaciclovir treatments may suggest that antivirals are also effective in the treatment of HPV lesions. The cases described could pave the way for further investigations and clinical studies.https://doi.org/10.1186/s13027-023-00511-0AcyclovirValacyclovirHHV-2HPVCondylomatosisSTI |
| spellingShingle | Maria Balestrieri Caterina Carnovale-Scalzo Anna Rosa Garbuglia Maria Vincenza Chiantore Luisa Accardi Paola Di Bonito Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series Infectious Agents and Cancer Acyclovir Valacyclovir HHV-2 HPV Condylomatosis STI |
| title | Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series |
| title_full | Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series |
| title_fullStr | Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series |
| title_full_unstemmed | Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series |
| title_short | Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series |
| title_sort | conventional therapy for genital herpesvirus and remission of hpv related lesions a case series |
| topic | Acyclovir Valacyclovir HHV-2 HPV Condylomatosis STI |
| url | https://doi.org/10.1186/s13027-023-00511-0 |
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