Gb3‐cSrc complex in glycosphingolipid‐enriched microdomains contributes to the expression of p53 mutant protein and cancer drug resistance via β‐catenin–activated RNA methylation

Gb3‐cSrc complex in glycosphingolipid‐enriched microdomains contributes to the expression of p53 mutant protein and cancer drug resistance via β‐catenin–activated RNA methylation

Abstract Glucosylceramide synthase (GCS) is a key enzyme catalyzing ceramide glycosylation to generate glucosylceramide (GlcCer), which in turn serves as the precursor for cells to produce glycosphingolipids (GSLs). In cell membranes, GSLs serve as essential components of GSL‐enriched microdomains (...

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Bibliographic Details
Main Authors: Kartik R. Roy, Mohammad B. Uddin, Sagor C. Roy, Ronald A. Hill, John Marshall, Yu‐Teh Li, Jean Christopher Chamcheu, Hua Lu, Yong‐Yu Liu
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:FASEB BioAdvances
Subjects:
colon cancer
cSrc kinase
drug resistance
glycosphingolipid‐enriched microdomains
glycosphingolipids
missense mutation
Online Access:https://doi.org/10.1096/fba.2020-00044

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