Ectonucleotidase-Mediated Suppression of Lupus Autoimmunity and Vascular Dysfunction

Ectonucleotidase-Mediated Suppression of Lupus Autoimmunity and Vascular Dysfunction

ObjectivesCD39 and CD73 are surface enzymes that jut into the extracellular space where they mediate the step-wise phosphohydrolysis of the autocrine and paracrine danger signals ATP and ADP into anti-inflammatory adenosine. Given the role of vascular and immune cells’ “purinergic halo” in maintaini...

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Bibliographic Details
Main Authors: Jason S. Knight, Levi F. Mazza, Srilakshmi Yalavarthi, Gautam Sule, Ramadan A. Ali, Jeffrey B. Hodgin, Yogendra Kanthi, David J. Pinsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
ectonucleotidases
CD73
CD39
TH17 cells
endothelial dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01322/full

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