Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats
Ginger and turmeric rhizomes are used in folk medicine for the treatment of hypertension but the mechanism remains unclear. This study evaluated the effects of ginger and turmeric rhizomes on angiotensin 1 converting enzyme (ACE) and arginase activities in hypertensive rats. The animals were divided...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-08-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464615002959 |
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| author | Ayodele Jacob Akinyemi Gustavo Roberto Thome Vera Maria Morsch Naiara Stefanello Jeferson Ferraz Goularte Adriane Belló-Klein Ganiyu Oboh Maria Rosa Chitolina Schetinger |
| author_facet | Ayodele Jacob Akinyemi Gustavo Roberto Thome Vera Maria Morsch Naiara Stefanello Jeferson Ferraz Goularte Adriane Belló-Klein Ganiyu Oboh Maria Rosa Chitolina Schetinger |
| author_sort | Ayodele Jacob Akinyemi |
| collection | DOAJ |
| description | Ginger and turmeric rhizomes are used in folk medicine for the treatment of hypertension but the mechanism remains unclear. This study evaluated the effects of ginger and turmeric rhizomes on angiotensin 1 converting enzyme (ACE) and arginase activities in hypertensive rats. The animals were divided into seven groups (n = 10): normotensive control rats; hypertensive rats; hypertensive rats treated with atenolol; normotensive diet group supplemented with turmeric rhizomes; hypertensive rats supplemented with turmeric rhizomes; normotensive diet group supplemented with ginger rhizomes; and hypertensive diet group supplemented with ginger rhizomes respectively. After 14 days of pre-treatment with ginger and turmeric rhizomes-supplemented diet, the animals were induced with hypertension by oral administration of Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME). The results revealed a significant increase in ACE and arginase activities in hypertensive rats when compared with the control. However, pre-treatment with both rhizomes respectively caused a significant decrease in ACE and arginase activities with a concomitant increase in nitric oxide (NO) level. These activities could further buttress their antihypertensive benefits in folk medicine. |
| first_indexed | 2024-12-14T10:41:54Z |
| format | Article |
| id | doaj.art-97412eaee6e8451aaf4c09f63946c042 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T10:41:54Z |
| publishDate | 2015-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-97412eaee6e8451aaf4c09f63946c0422022-12-21T23:05:39ZengElsevierJournal of Functional Foods1756-46462015-08-0117792801Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive ratsAyodele Jacob Akinyemi0Gustavo Roberto Thome1Vera Maria Morsch2Naiara Stefanello3Jeferson Ferraz Goularte4Adriane Belló-Klein5Ganiyu Oboh6Maria Rosa Chitolina Schetinger7Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology Akure, Private Mail Bag 704, Akure 340001, Nigeria; Department of Biochemistry, Afe Babalola University Ado-Ekiti, Private Mail Bag 5454, Nigeria; Programa de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Santa Maria, RS CEP 97105-900, BrazilPrograma de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Santa Maria, RS CEP 97105-900, BrazilPrograma de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Santa Maria, RS CEP 97105-900, BrazilPrograma de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Santa Maria, RS CEP 97105-900, BrazilHealth Basic Sciences Institute, Department of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, RS, BrazilHealth Basic Sciences Institute, Department of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, RS, BrazilFunctional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology Akure, Private Mail Bag 704, Akure 340001, Nigeria; Corresponding author. Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology Akure, Private Mail Bag 704, Akure 34000157. ia.Programa de Pós Graduação em Ciências Biológicas, Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Santa Maria, RS CEP 97105-900, Brazil; Corresponding author. Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria (UFSM), CEP 97105-900, Santa Maria/RS, Brazil. Tel.: +55 55 3220 9557; fax: +55 55 3220 9557.Ginger and turmeric rhizomes are used in folk medicine for the treatment of hypertension but the mechanism remains unclear. This study evaluated the effects of ginger and turmeric rhizomes on angiotensin 1 converting enzyme (ACE) and arginase activities in hypertensive rats. The animals were divided into seven groups (n = 10): normotensive control rats; hypertensive rats; hypertensive rats treated with atenolol; normotensive diet group supplemented with turmeric rhizomes; hypertensive rats supplemented with turmeric rhizomes; normotensive diet group supplemented with ginger rhizomes; and hypertensive diet group supplemented with ginger rhizomes respectively. After 14 days of pre-treatment with ginger and turmeric rhizomes-supplemented diet, the animals were induced with hypertension by oral administration of Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME). The results revealed a significant increase in ACE and arginase activities in hypertensive rats when compared with the control. However, pre-treatment with both rhizomes respectively caused a significant decrease in ACE and arginase activities with a concomitant increase in nitric oxide (NO) level. These activities could further buttress their antihypertensive benefits in folk medicine.http://www.sciencedirect.com/science/article/pii/S1756464615002959GingerHypertensionL-NAMEACEArginaseNO |
| spellingShingle | Ayodele Jacob Akinyemi Gustavo Roberto Thome Vera Maria Morsch Naiara Stefanello Jeferson Ferraz Goularte Adriane Belló-Klein Ganiyu Oboh Maria Rosa Chitolina Schetinger Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats Journal of Functional Foods Ginger Hypertension L-NAME ACE Arginase NO |
| title | Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats |
| title_full | Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats |
| title_fullStr | Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats |
| title_full_unstemmed | Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats |
| title_short | Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats |
| title_sort | effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin 1 converting enzyme ace and arginase activities in l name induced hypertensive rats |
| topic | Ginger Hypertension L-NAME ACE Arginase NO |
| url | http://www.sciencedirect.com/science/article/pii/S1756464615002959 |
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