The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target
Alzheimer’s disease is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, emerging evidence suggests that neuroinflammation, mediated notably by activated neuroglial cells, neutrophils, and macrophages, also plays an important role in the pathogen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/864 |
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| author | Marta Rusek Joanna Smith Kamel El-Khatib Kennedy Aikins Stanisław J. Czuczwar Ryszard Pluta |
| author_facet | Marta Rusek Joanna Smith Kamel El-Khatib Kennedy Aikins Stanisław J. Czuczwar Ryszard Pluta |
| author_sort | Marta Rusek |
| collection | DOAJ |
| description | Alzheimer’s disease is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, emerging evidence suggests that neuroinflammation, mediated notably by activated neuroglial cells, neutrophils, and macrophages, also plays an important role in the pathogenesis of Alzheimer’s disease. Therefore, understanding the interplay between the nervous and immune systems might be the key to the prevention or delay of Alzheimer’s disease progression. One of the most important mechanisms determining gliogenic cell fate is the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway that is influenced by the overactivation of microglia and astrocytes. The JAK/STAT signaling pathway is one of the critical factors that promote neuroinflammation in neurodegenerative diseases such as Alzheimer’s disease by initiating innate immunity, orchestrating adaptive immune mechanisms, and finally, constraining neuroinflammatory response. Since a chronic neuroinflammatory environment in the brain is a hallmark of Alzheimer’s disease, understanding the process would allow establishing the underlying role of neuroinflammation, then estimating the prognosis of Alzheimer’s disease development and finding a new potential treatment target. In this review, we highlight the recent advances in the potential role of JAK/STAT signaling in neurological diseases with a focus on discussing future research directions regarding novel therapeutic approaches and predictive biomarkers for Alzheimer’s disease. |
| first_indexed | 2024-03-11T09:58:03Z |
| format | Article |
| id | doaj.art-9742379f702044c7a2221849a2307bc9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:58:03Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9742379f702044c7a2221849a2307bc92023-11-16T15:39:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-0124186410.3390/ijms24010864The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment TargetMarta Rusek0Joanna Smith1Kamel El-Khatib2Kennedy Aikins3Stanisław J. Czuczwar4Ryszard Pluta5Department of Pathophysiology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Pathophysiology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Pathophysiology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Pathophysiology, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Pathophysiology, Medical University of Lublin, 20-090 Lublin, PolandLaboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandAlzheimer’s disease is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, emerging evidence suggests that neuroinflammation, mediated notably by activated neuroglial cells, neutrophils, and macrophages, also plays an important role in the pathogenesis of Alzheimer’s disease. Therefore, understanding the interplay between the nervous and immune systems might be the key to the prevention or delay of Alzheimer’s disease progression. One of the most important mechanisms determining gliogenic cell fate is the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway that is influenced by the overactivation of microglia and astrocytes. The JAK/STAT signaling pathway is one of the critical factors that promote neuroinflammation in neurodegenerative diseases such as Alzheimer’s disease by initiating innate immunity, orchestrating adaptive immune mechanisms, and finally, constraining neuroinflammatory response. Since a chronic neuroinflammatory environment in the brain is a hallmark of Alzheimer’s disease, understanding the process would allow establishing the underlying role of neuroinflammation, then estimating the prognosis of Alzheimer’s disease development and finding a new potential treatment target. In this review, we highlight the recent advances in the potential role of JAK/STAT signaling in neurological diseases with a focus on discussing future research directions regarding novel therapeutic approaches and predictive biomarkers for Alzheimer’s disease.https://www.mdpi.com/1422-0067/24/1/864Alzheimer’s diseaseJAK/STAT signaling pathwayneuroinflammationneuroprotectiontreatment |
| spellingShingle | Marta Rusek Joanna Smith Kamel El-Khatib Kennedy Aikins Stanisław J. Czuczwar Ryszard Pluta The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target International Journal of Molecular Sciences Alzheimer’s disease JAK/STAT signaling pathway neuroinflammation neuroprotection treatment |
| title | The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target |
| title_full | The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target |
| title_fullStr | The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target |
| title_full_unstemmed | The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target |
| title_short | The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target |
| title_sort | role of the jak stat signaling pathway in the pathogenesis of alzheimer s disease new potential treatment target |
| topic | Alzheimer’s disease JAK/STAT signaling pathway neuroinflammation neuroprotection treatment |
| url | https://www.mdpi.com/1422-0067/24/1/864 |
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