Calmodulin- and Ca2+-Dependent Facilitation and Inactivation of the CaV 1.2 Ca2+ Channels in Guinea-Pig Ventricular Myocytes
The L-type Ca2+ channel (Ca V 1.2) shows clear Ca2+-dependent facilitation and inactivation. Here we have examined the effects of calmodulin (CaM) and Ca2+ on Ca2+ channel in guinea-pig ventricular myocytes in the inside-out patch mode, where rundown of the channels was controlled. At a free [Ca2+]...
Main Authors: | Dong-Yun Han, Etsuko Minobe, Wu-Yang Wang, Feng Guo, Jian-Jun Xu, Li-Ying Hao, Masaki Kameyama |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2010-01-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319309995 |
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