RITUXIMAB IN PEDIATRIC RHEUMATOLOGY

<p><em>The article presents literature review on the role of B-lymphocytes in pathogenesis of rheumatologic diseases and on the administration of chimeric anti-CD20 monoclonal antibodies — rituximab — for treatment of systemic lupus erythematosus, systemic vasculitis, juvenile dermatomyo...

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Main Authors: E.I. Alexeeva, R.V. Denisova, S.I. Valieva, T.M. Bzarova, A.O. Lisitsyn
Format: Article
Language:English
Published: "Paediatrician" Publishers LLC 2010-01-01
Series:Вопросы современной педиатрии
Online Access:http://vsp.spr-journal.ru:80/jour/article/view/891
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author E.I. Alexeeva
R.V. Denisova
S.I. Valieva
T.M. Bzarova
A.O. Lisitsyn
author_facet E.I. Alexeeva
R.V. Denisova
S.I. Valieva
T.M. Bzarova
A.O. Lisitsyn
author_sort E.I. Alexeeva
collection DOAJ
description <p><em>The article presents literature review on the role of B-lymphocytes in pathogenesis of rheumatologic diseases and on the administration of chimeric anti-CD20 monoclonal antibodies — rituximab — for treatment of systemic lupus erythematosus, systemic vasculitis, juvenile dermatomyositis, and juvenile arthritis in children. Results of studies showed that rituximab has good tolerability, efficacy and safety in children’s rheumatologic practice.</em><strong><em></em></strong></p><p><strong><em>Key words: children, B-lymphocytes, rituximab, treatment, depletion.</em></strong><br /><span style="text-decoration: underline;"><em>(<em><em>Voprosy sovremennoi pediatrii — </em></em>Current Pediatrics. – 2010;9(3):<em>54-62</em>)</em></span></p>
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spelling doaj.art-97433776ccd747979c6f2d6c2ce61a922023-09-02T23:45:59Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352010-01-01935462892RITUXIMAB IN PEDIATRIC RHEUMATOLOGYE.I. Alexeeva0R.V. Denisova1S.I. Valieva2T.M. Bzarova3A.O. Lisitsyn4Scientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow<p><em>The article presents literature review on the role of B-lymphocytes in pathogenesis of rheumatologic diseases and on the administration of chimeric anti-CD20 monoclonal antibodies — rituximab — for treatment of systemic lupus erythematosus, systemic vasculitis, juvenile dermatomyositis, and juvenile arthritis in children. Results of studies showed that rituximab has good tolerability, efficacy and safety in children’s rheumatologic practice.</em><strong><em></em></strong></p><p><strong><em>Key words: children, B-lymphocytes, rituximab, treatment, depletion.</em></strong><br /><span style="text-decoration: underline;"><em>(<em><em>Voprosy sovremennoi pediatrii — </em></em>Current Pediatrics. – 2010;9(3):<em>54-62</em>)</em></span></p>http://vsp.spr-journal.ru:80/jour/article/view/891
spellingShingle E.I. Alexeeva
R.V. Denisova
S.I. Valieva
T.M. Bzarova
A.O. Lisitsyn
RITUXIMAB IN PEDIATRIC RHEUMATOLOGY
Вопросы современной педиатрии
title RITUXIMAB IN PEDIATRIC RHEUMATOLOGY
title_full RITUXIMAB IN PEDIATRIC RHEUMATOLOGY
title_fullStr RITUXIMAB IN PEDIATRIC RHEUMATOLOGY
title_full_unstemmed RITUXIMAB IN PEDIATRIC RHEUMATOLOGY
title_short RITUXIMAB IN PEDIATRIC RHEUMATOLOGY
title_sort rituximab in pediatric rheumatology
url http://vsp.spr-journal.ru:80/jour/article/view/891
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AT rvdenisova rituximabinpediatricrheumatology
AT sivalieva rituximabinpediatricrheumatology
AT tmbzarova rituximabinpediatricrheumatology
AT aolisitsyn rituximabinpediatricrheumatology