PREDICTORS OF EARLY AND DELAYED GRAFT FUNCTION IN LIVE AND CADAVERIC RENAL TRANSPLANTATION
Background: Kidney transplantation gives the best quality of life to chronic kidney disease patients and also increases longevity. Aim: Analysis of factors responsible for the early and delayed graft functioning in live and cadaver renal transplants Methods: It was a retrospective observational st...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
university of basrah
2023-06-01
|
| Series: | Basrah Journal of Surgery |
| Subjects: | |
| Online Access: | https://www.iasj.net/iasj/pdf/65a7927c9d53122b |
| _version_ | 1797779804653617152 |
|---|---|
| author | SUNIL SATIHAL Sandeep Kumar Reddy Ifrah Ahmad Qazi RAHUL DEVRAJ DHEERAJ SSS |
| author_facet | SUNIL SATIHAL Sandeep Kumar Reddy Ifrah Ahmad Qazi RAHUL DEVRAJ DHEERAJ SSS |
| author_sort | SUNIL SATIHAL |
| collection | DOAJ |
| description | Background: Kidney transplantation gives the best quality of life to chronic kidney disease patients and also increases longevity.
Aim: Analysis of factors responsible for the early and delayed graft functioning in live and cadaver renal transplants
Methods: It was a retrospective observational study. Donor and recipient age, sex, BMI, comorbid illness, and functioning status of the donor kidney, duration and severity of chronic kidney disease and associated bladder disorders were collected. Operative factors like perfusion time, cold ischemia time, blood pressure fall, need for blood transfusion, vasopressor support was recorded. Patients were divided into two groups based on early versus delayed graft function.
Results: 27 cases of Live donor renal transplant and 23 cadaver transplants were included. The average age in live donor and cadaveric transplants was 43.5 ±7.6 years and 38.3 ±10.5 years, respectively. 24 Live Transplant Recipients had Early Graft function (89%). Seven Cadaveric Transplant Recipients had Early Graft function (31%) and 16 of them had Delayed Graft Function (69%). HLA Mismatch, Perioperative Hypotension and BMI of recipient had statistically significant relationship to Early Graft Function with p values of 0.02, 0.004 and 0.007, respectively. With p-value of 0.021 and of 0.046, respectively, perioperative hypotension and cold ischemic time in Cadaveric renal transplantation had statistically significant relationship to Early Graft Function.
Conclusion: Live donor transplants have better early graft function. HLA Mismatch, Perioperative Hypotension, BMI of recipient and cold ischemic time in Cadaveric renal transplantation are the predictors of early graft function.
Keywords
Cadaveric,, ,،,؛Kidney transplantation,, ,،,؛
|
| first_indexed | 2024-03-12T23:35:58Z |
| format | Article |
| id | doaj.art-974417c5a0df4d95a26f0bed4aa1467e |
| institution | Directory Open Access Journal |
| issn | 1683-3589 2409-501X |
| language | English |
| last_indexed | 2024-03-12T23:35:58Z |
| publishDate | 2023-06-01 |
| publisher | university of basrah |
| record_format | Article |
| series | Basrah Journal of Surgery |
| spelling | doaj.art-974417c5a0df4d95a26f0bed4aa1467e2023-07-15T11:12:01Zenguniversity of basrahBasrah Journal of Surgery1683-35892409-501X2023-06-0129141410.33762/bsurg.2022.135361.1029PREDICTORS OF EARLY AND DELAYED GRAFT FUNCTION IN LIVE AND CADAVERIC RENAL TRANSPLANTATIONSUNIL SATIHAL0Sandeep Kumar Reddy1Ifrah Ahmad Qazi2RAHUL DEVRAJ3DHEERAJ SSS4Department of Urology, Nizam’s Institute of Medical SciencesDepartment Of Urology, Narayana Medical College, NelloreDepartment Of Urology, Narayana Medical College, NelloreDepartment of Urology, Nizam’s Institute of Medical Sciences , HyderabadDepartment of Urology, Nizam’s Institute of Medical Sciences , Hyderabad , Telangana ,India.Background: Kidney transplantation gives the best quality of life to chronic kidney disease patients and also increases longevity. Aim: Analysis of factors responsible for the early and delayed graft functioning in live and cadaver renal transplants Methods: It was a retrospective observational study. Donor and recipient age, sex, BMI, comorbid illness, and functioning status of the donor kidney, duration and severity of chronic kidney disease and associated bladder disorders were collected. Operative factors like perfusion time, cold ischemia time, blood pressure fall, need for blood transfusion, vasopressor support was recorded. Patients were divided into two groups based on early versus delayed graft function. Results: 27 cases of Live donor renal transplant and 23 cadaver transplants were included. The average age in live donor and cadaveric transplants was 43.5 ±7.6 years and 38.3 ±10.5 years, respectively. 24 Live Transplant Recipients had Early Graft function (89%). Seven Cadaveric Transplant Recipients had Early Graft function (31%) and 16 of them had Delayed Graft Function (69%). HLA Mismatch, Perioperative Hypotension and BMI of recipient had statistically significant relationship to Early Graft Function with p values of 0.02, 0.004 and 0.007, respectively. With p-value of 0.021 and of 0.046, respectively, perioperative hypotension and cold ischemic time in Cadaveric renal transplantation had statistically significant relationship to Early Graft Function. Conclusion: Live donor transplants have better early graft function. HLA Mismatch, Perioperative Hypotension, BMI of recipient and cold ischemic time in Cadaveric renal transplantation are the predictors of early graft function. Keywords Cadaveric,, ,،,؛Kidney transplantation,, ,،,؛ https://www.iasj.net/iasj/pdf/65a7927c9d53122bcadaveric؛kidney transplantationearly graft function |
| spellingShingle | SUNIL SATIHAL Sandeep Kumar Reddy Ifrah Ahmad Qazi RAHUL DEVRAJ DHEERAJ SSS PREDICTORS OF EARLY AND DELAYED GRAFT FUNCTION IN LIVE AND CADAVERIC RENAL TRANSPLANTATION Basrah Journal of Surgery cadaveric ؛kidney transplantation early graft function |
| title | PREDICTORS OF EARLY AND DELAYED GRAFT FUNCTION IN LIVE AND CADAVERIC RENAL TRANSPLANTATION |
| title_full | PREDICTORS OF EARLY AND DELAYED GRAFT FUNCTION IN LIVE AND CADAVERIC RENAL TRANSPLANTATION |
| title_fullStr | PREDICTORS OF EARLY AND DELAYED GRAFT FUNCTION IN LIVE AND CADAVERIC RENAL TRANSPLANTATION |
| title_full_unstemmed | PREDICTORS OF EARLY AND DELAYED GRAFT FUNCTION IN LIVE AND CADAVERIC RENAL TRANSPLANTATION |
| title_short | PREDICTORS OF EARLY AND DELAYED GRAFT FUNCTION IN LIVE AND CADAVERIC RENAL TRANSPLANTATION |
| title_sort | predictors of early and delayed graft function in live and cadaveric renal transplantation |
| topic | cadaveric ؛kidney transplantation early graft function |
| url | https://www.iasj.net/iasj/pdf/65a7927c9d53122b |
| work_keys_str_mv | AT sunilsatihal predictorsofearlyanddelayedgraftfunctioninliveandcadavericrenaltransplantation AT sandeepkumarreddy predictorsofearlyanddelayedgraftfunctioninliveandcadavericrenaltransplantation AT ifrahahmadqazi predictorsofearlyanddelayedgraftfunctioninliveandcadavericrenaltransplantation AT rahuldevraj predictorsofearlyanddelayedgraftfunctioninliveandcadavericrenaltransplantation AT dheerajsss predictorsofearlyanddelayedgraftfunctioninliveandcadavericrenaltransplantation |