Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome
<b>Background:</b> To investigate gender differences in epicardial adipose tissue (EAT) and plaque composition by coronary CT angiography (CCTA) and the association with cardiovascular outcome. <b>Methods:</b> Data of 352 patients (64.2 ± 10.3 years, 38% female) with suspecte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/4/624 |
| _version_ | 1797621518130216960 |
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| author | Ullrich Ebersberger Maximilian J. Bauer Florian Straube Nicola Fink U. Joseph Schoepf Akos Varga-Szemes Tilman Emrich Joseph Griffith Ellen Hoffmann Christian Tesche |
| author_facet | Ullrich Ebersberger Maximilian J. Bauer Florian Straube Nicola Fink U. Joseph Schoepf Akos Varga-Szemes Tilman Emrich Joseph Griffith Ellen Hoffmann Christian Tesche |
| author_sort | Ullrich Ebersberger |
| collection | DOAJ |
| description | <b>Background:</b> To investigate gender differences in epicardial adipose tissue (EAT) and plaque composition by coronary CT angiography (CCTA) and the association with cardiovascular outcome. <b>Methods:</b> Data of 352 patients (64.2 ± 10.3 years, 38% female) with suspected coronary artery disease (CAD) who underwent CCTA were retrospectively analyzed. EAT volume and plaque composition from CCTA were compared between men and women. Major adverse cardiovascular events (MACE) were recorded from follow-up. <b>Results:</b> Men were more likely to have obstructive CAD, higher Agatston scores, and a larger total and non-calcified plaque burden. In addition, men displayed more adverse plaque characteristics and EAT volume compared to women (all <i>p</i> < 0.05). After a median follow-up of 5.1 years, MACE occurred in 8 women (6%) and 22 men (10%). In multivariable analysis, Agatston calcium score (HR 1.0008, <i>p</i> = 0.014), EAT volume (HR 1.067, <i>p</i> = 0.049), and low-attenuation plaque (HR 3.82, <i>p</i> = 0.036) were independent predictors for MACE in men, whereas only low-attenuation plaque (HR 2.42, <i>p</i> = 0.041) showed predictive value for events in women. <b>Conclusion:</b> Women demonstrated less overall plaque burden, fewer adverse plaque characteristics, and a smaller EAT volume compared to men. However, low-attenuation plaque is a predictor for MACE in both genders. Thus, a differentiated plaque analysis is warranted to understand gender differences of atherosclerosis to guide medical therapy and prevention strategies. |
| first_indexed | 2024-03-11T08:57:08Z |
| format | Article |
| id | doaj.art-9744837004c7497b99973c2214e39f0e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:57:08Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-9744837004c7497b99973c2214e39f0e2023-11-16T20:00:36ZengMDPI AGDiagnostics2075-44182023-02-0113462410.3390/diagnostics13040624Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular OutcomeUllrich Ebersberger0Maximilian J. Bauer1Florian Straube2Nicola Fink3U. Joseph Schoepf4Akos Varga-Szemes5Tilman Emrich6Joseph Griffith7Ellen Hoffmann8Christian Tesche9Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, 80636 Munich, GermanyDepartment of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, 81925 Munich, GermanyDepartment of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, 81925 Munich, GermanyDivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC 29425, USADivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC 29425, USADivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC 29425, USADivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC 29425, USADivision of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, 81925 Munich, GermanyDepartment of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, 80636 Munich, Germany<b>Background:</b> To investigate gender differences in epicardial adipose tissue (EAT) and plaque composition by coronary CT angiography (CCTA) and the association with cardiovascular outcome. <b>Methods:</b> Data of 352 patients (64.2 ± 10.3 years, 38% female) with suspected coronary artery disease (CAD) who underwent CCTA were retrospectively analyzed. EAT volume and plaque composition from CCTA were compared between men and women. Major adverse cardiovascular events (MACE) were recorded from follow-up. <b>Results:</b> Men were more likely to have obstructive CAD, higher Agatston scores, and a larger total and non-calcified plaque burden. In addition, men displayed more adverse plaque characteristics and EAT volume compared to women (all <i>p</i> < 0.05). After a median follow-up of 5.1 years, MACE occurred in 8 women (6%) and 22 men (10%). In multivariable analysis, Agatston calcium score (HR 1.0008, <i>p</i> = 0.014), EAT volume (HR 1.067, <i>p</i> = 0.049), and low-attenuation plaque (HR 3.82, <i>p</i> = 0.036) were independent predictors for MACE in men, whereas only low-attenuation plaque (HR 2.42, <i>p</i> = 0.041) showed predictive value for events in women. <b>Conclusion:</b> Women demonstrated less overall plaque burden, fewer adverse plaque characteristics, and a smaller EAT volume compared to men. However, low-attenuation plaque is a predictor for MACE in both genders. Thus, a differentiated plaque analysis is warranted to understand gender differences of atherosclerosis to guide medical therapy and prevention strategies.https://www.mdpi.com/2075-4418/13/4/624coronary computed tomography angiographycoronary artery diseasecardiovascular outcomegenderplaque quantificationepicardial adipose tissue |
| spellingShingle | Ullrich Ebersberger Maximilian J. Bauer Florian Straube Nicola Fink U. Joseph Schoepf Akos Varga-Szemes Tilman Emrich Joseph Griffith Ellen Hoffmann Christian Tesche Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome Diagnostics coronary computed tomography angiography coronary artery disease cardiovascular outcome gender plaque quantification epicardial adipose tissue |
| title | Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome |
| title_full | Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome |
| title_fullStr | Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome |
| title_full_unstemmed | Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome |
| title_short | Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome |
| title_sort | gender differences in epicardial adipose tissue and plaque composition by coronary ct angiography association with cardiovascular outcome |
| topic | coronary computed tomography angiography coronary artery disease cardiovascular outcome gender plaque quantification epicardial adipose tissue |
| url | https://www.mdpi.com/2075-4418/13/4/624 |
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