Palmitate-induced Slc2a4/GLUT4 downregulation in L6 muscle cells: evidence of inflammatory and endoplasmic reticulum stress involvement

Palmitate-induced Slc2a4/GLUT4 downregulation in L6 muscle cells: evidence of inflammatory and endoplasmic reticulum stress involvement

Abstract Background Obesity is strongly associated to insulin resistance, inflammation, and elevated plasma free fatty acids, but the mechanisms behind this association are not fully comprehended. Evidences suggest that endoplasmic reticulum (ER) stress may play a role in this complex pathophysiolog...

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Main Authors: Patrícia Ebersbach-Silva, Ana Cláudia Poletto, Aline David-Silva, Patrícia Monteiro Seraphim, Gabriel Forato Anhê, Marisa Passarelli, Daniela Tomie Furuya, Ubiratan Fabres Machado
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Lipids in Health and Disease
Subjects:
Palmitate
GLUT4
ER stress
NFKB
L6 cells
Insulin resistance
Online Access:http://link.springer.com/article/10.1186/s12944-018-0714-8

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