Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate
We present a case of a neonate born with kaposiform hemangioendothelioma (KHE), complicated by Kasabach-Merritt phenomenon (KMP) and other serious conditions, who was successfully treated with sirolimus. In addition to complications from thrombocytopenia and fluid overload, during the course of ther...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2020-10-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1718901 |
| _version_ | 1811292915034488832 |
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| author | Trevor B. Cabrera Allison L. Speer Matthew R. Greives Donna A. Goff Neethu M. Menon Eric W. Reynolds |
| author_facet | Trevor B. Cabrera Allison L. Speer Matthew R. Greives Donna A. Goff Neethu M. Menon Eric W. Reynolds |
| author_sort | Trevor B. Cabrera |
| collection | DOAJ |
| description | We present a case of a neonate born with kaposiform hemangioendothelioma (KHE), complicated by Kasabach-Merritt phenomenon (KMP) and other serious conditions, who was successfully treated with sirolimus. In addition to complications from thrombocytopenia and fluid overload, during the course of therapy, our patient experienced supratherapeutic drug levels at the commonly accepted starting dose of sirolimus. Patients with KHE and KMP should be closely monitored for potential complications of both the initial disease and unexpected side effects of treatments. |
| first_indexed | 2024-04-13T04:53:36Z |
| format | Article |
| id | doaj.art-9745bb35c32d40f594ac59930df68a5f |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-04-13T04:53:36Z |
| publishDate | 2020-10-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-9745bb35c32d40f594ac59930df68a5f2022-12-22T03:01:36ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052020-10-011004e390e39410.1055/s-0040-1718901Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a NeonateTrevor B. Cabrera0Allison L. Speer1Matthew R. Greives2Donna A. Goff3Neethu M. Menon4Eric W. Reynolds5Department of Pediatrics, University of Texas Health Science Center at Houston/McGovern Medical School, Houston, TexasDepartment of Pediatric Surgery, University of Texas Health Science Center at Houston/McGovern Medical School, Houston, TexasDepartment of Pediatric Plastic Surgery, University of Texas Health Science Center at Houston/McGovern Medical School, Houston, TexasDepartment of Pediatric Cardiology, University of Texas Health Science Center at Houston/McGovern Medical School, Houston, TexasDepartment of Pediatric Hematology, University of Texas Health Science Center at Houston/McGovern Medical School, Houston, TexasDepartment of Neonatal/Perinatal Medicine, University of Texas Health Science Center at Houston/McGovern Medical School, Houston, TexasWe present a case of a neonate born with kaposiform hemangioendothelioma (KHE), complicated by Kasabach-Merritt phenomenon (KMP) and other serious conditions, who was successfully treated with sirolimus. In addition to complications from thrombocytopenia and fluid overload, during the course of therapy, our patient experienced supratherapeutic drug levels at the commonly accepted starting dose of sirolimus. Patients with KHE and KMP should be closely monitored for potential complications of both the initial disease and unexpected side effects of treatments.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1718901kaposiform hemangioendotheliomakasabach-merritt phenomenonsirolimus |
| spellingShingle | Trevor B. Cabrera Allison L. Speer Matthew R. Greives Donna A. Goff Neethu M. Menon Eric W. Reynolds Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate American Journal of Perinatology Reports kaposiform hemangioendothelioma kasabach-merritt phenomenon sirolimus |
| title | Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate |
| title_full | Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate |
| title_fullStr | Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate |
| title_full_unstemmed | Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate |
| title_short | Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate |
| title_sort | sirolimus for kaposiform hemangioendothelioma and kasabach merritt phenomenon in a neonate |
| topic | kaposiform hemangioendothelioma kasabach-merritt phenomenon sirolimus |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1718901 |
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