Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H<sub>2</sub>O<sub>2</sub>
Non-enzymatic sensing has been in the research limelight, and most sensors based on nanomaterials are designed to detect single analytes. The simultaneous detection of analytes that together exist in biological organisms necessitates the development of effective and efficient non-enzymatic electrode...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/10/11/151 |
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| author | Dayakar Thatikayala Deepalekshmi Ponnamma Kishor Kumar Sadasivuni John-John Cabibihan Abdulaziz Khalid Al-Ali Rayaz A. Malik Booki Min |
| author_facet | Dayakar Thatikayala Deepalekshmi Ponnamma Kishor Kumar Sadasivuni John-John Cabibihan Abdulaziz Khalid Al-Ali Rayaz A. Malik Booki Min |
| author_sort | Dayakar Thatikayala |
| collection | DOAJ |
| description | Non-enzymatic sensing has been in the research limelight, and most sensors based on nanomaterials are designed to detect single analytes. The simultaneous detection of analytes that together exist in biological organisms necessitates the development of effective and efficient non-enzymatic electrodes in sensing. In this regard, the development of sensing elements for detecting glucose and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is significant. Non-enzymatic sensing is more economical and has a longer lifetime than enzymatic electrochemical sensing, but it has several drawbacks, such as high working potential, slow electrode kinetics, poisoning from intermediate species and weak sensing parameters. We comprehensively review the recent developments in non-enzymatic glucose and H<sub>2</sub>O<sub>2</sub> (NEGH) sensing by focusing mainly on the sensing performance, electro catalytic mechanism, morphology and design of electrode materials. Various types of nanomaterials with metal/metal oxides and hybrid metallic nanocomposites are discussed. A comparison of glucose and H<sub>2</sub>O<sub>2</sub> sensing parameters using the same electrode materials is outlined to predict the efficient sensing performance of advanced nanomaterials. Recent innovative approaches to improve the NEGH sensitivity, selectivity and stability in real-time applications are critically discussed, which have not been sufficiently addressed in the previous reviews. Finally, the challenges, future trends, and prospects associated with advanced nanomaterials for NEGH sensing are considered. We believe this article will help to understand the selection of advanced materials for dual/multi non-enzymatic sensing issues and will also be beneficial for researchers to make breakthrough progress in the area of non-enzymatic sensing of dual/multi biomolecules. |
| first_indexed | 2024-03-10T15:25:48Z |
| format | Article |
| id | doaj.art-9747e22daade4472b7154ec630275150 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T15:25:48Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-9747e22daade4472b7154ec6302751502023-11-20T18:03:08ZengMDPI AGBiosensors2079-63742020-10-01101115110.3390/bios10110151Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H<sub>2</sub>O<sub>2</sub>Dayakar Thatikayala0Deepalekshmi Ponnamma1Kishor Kumar Sadasivuni2John-John Cabibihan3Abdulaziz Khalid Al-Ali4Rayaz A. Malik5Booki Min6Department of Environment Science and Engineering, Kyung Hee University, Yongin 446-701, KoreaCenter for Advanced Materials, Qatar University, P.O. Box 2713, Doha, QatarCenter for Advanced Materials, Qatar University, P.O. Box 2713, Doha, QatarDepartment of Mechanical and Industrial Engineering, Qatar University, P.O. Box 2713, Doha, QatarDepartment of Computer Engineering, Qatar University, P.O. Box 2713, Doha, QatarWeill Cornell Medicine-Qatar, Qatar Foundation-Education City, P.O. Box 24144, Doha, QatarDepartment of Environment Science and Engineering, Kyung Hee University, Yongin 446-701, KoreaNon-enzymatic sensing has been in the research limelight, and most sensors based on nanomaterials are designed to detect single analytes. The simultaneous detection of analytes that together exist in biological organisms necessitates the development of effective and efficient non-enzymatic electrodes in sensing. In this regard, the development of sensing elements for detecting glucose and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is significant. Non-enzymatic sensing is more economical and has a longer lifetime than enzymatic electrochemical sensing, but it has several drawbacks, such as high working potential, slow electrode kinetics, poisoning from intermediate species and weak sensing parameters. We comprehensively review the recent developments in non-enzymatic glucose and H<sub>2</sub>O<sub>2</sub> (NEGH) sensing by focusing mainly on the sensing performance, electro catalytic mechanism, morphology and design of electrode materials. Various types of nanomaterials with metal/metal oxides and hybrid metallic nanocomposites are discussed. A comparison of glucose and H<sub>2</sub>O<sub>2</sub> sensing parameters using the same electrode materials is outlined to predict the efficient sensing performance of advanced nanomaterials. Recent innovative approaches to improve the NEGH sensitivity, selectivity and stability in real-time applications are critically discussed, which have not been sufficiently addressed in the previous reviews. Finally, the challenges, future trends, and prospects associated with advanced nanomaterials for NEGH sensing are considered. We believe this article will help to understand the selection of advanced materials for dual/multi non-enzymatic sensing issues and will also be beneficial for researchers to make breakthrough progress in the area of non-enzymatic sensing of dual/multi biomolecules.https://www.mdpi.com/2079-6374/10/11/151advanced nanomaterialsdual in-line sensingbi-functional propertiesnon-enzymaticelectrochemical sensingglucose and H<sub>2</sub>O<sub>2</sub> |
| spellingShingle | Dayakar Thatikayala Deepalekshmi Ponnamma Kishor Kumar Sadasivuni John-John Cabibihan Abdulaziz Khalid Al-Ali Rayaz A. Malik Booki Min Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H<sub>2</sub>O<sub>2</sub> Biosensors advanced nanomaterials dual in-line sensing bi-functional properties non-enzymatic electrochemical sensing glucose and H<sub>2</sub>O<sub>2</sub> |
| title | Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H<sub>2</sub>O<sub>2</sub> |
| title_full | Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H<sub>2</sub>O<sub>2</sub> |
| title_fullStr | Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H<sub>2</sub>O<sub>2</sub> |
| title_full_unstemmed | Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H<sub>2</sub>O<sub>2</sub> |
| title_short | Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H<sub>2</sub>O<sub>2</sub> |
| title_sort | progress of advanced nanomaterials in the non enzymatic electrochemical sensing of glucose and h sub 2 sub o sub 2 sub |
| topic | advanced nanomaterials dual in-line sensing bi-functional properties non-enzymatic electrochemical sensing glucose and H<sub>2</sub>O<sub>2</sub> |
| url | https://www.mdpi.com/2079-6374/10/11/151 |
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