The Protective Effect of CBD in a Model of In Vitro Ischemia May Be Mediated by Agonism on TRPV2 Channel and Microglia Activation

The Protective Effect of CBD in a Model of In Vitro Ischemia May Be Mediated by Agonism on TRPV2 Channel and Microglia Activation

Cannabinoids, used for centuries for recreational and medical purposes, have potential therapeutic value in stroke treatment. Cannabidiol (CBD), a non-psychoactive compound and partial agonist of TRPV2 channels, is efficacious in many neurological disorders. We investigated the effects of CBD or Δ9-...

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Bibliographic Details
Main Authors: Daniele Lana, Elisa Landucci, Costanza Mazzantini, Giada Magni, Domenico Edoardo Pellegrini-Giampietro, Maria Grazia Giovannini
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
cannabidiol
Δ-9-tetrahydrocannabinol
ischemia
neuroprotection
microglia
astrocytes
Online Access:https://www.mdpi.com/1422-0067/23/20/12144

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