Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge
Metastatic disease is a complex and sequential process that involves the migration of tumor cells from the primary site to distant areas. This metastatic pathway is not always predictable. Therefore, this paper presents three rare cases of unusual metastases, due to their primary site: two metastase...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/23/3513 |
| _version_ | 1797400334065205248 |
|---|---|
| author | Raluca-Maria Closca Adrian Nicoara Marina Rakitovan Ion Cristian Mot Flavia Baderca |
| author_facet | Raluca-Maria Closca Adrian Nicoara Marina Rakitovan Ion Cristian Mot Flavia Baderca |
| author_sort | Raluca-Maria Closca |
| collection | DOAJ |
| description | Metastatic disease is a complex and sequential process that involves the migration of tumor cells from the primary site to distant areas. This metastatic pathway is not always predictable. Therefore, this paper presents three rare cases of unusual metastases, due to their primary site: two metastases of a clear cell renal cell carcinoma, one gingival, and one nasal, as well as a mandibular metastasis of a hepatocellular carcinoma. In all cases, an incisional biopsy was performed in order to find out the diagnosis. After microscopical examination of morphological Hematoxylin and Eosin-stained slides, for all cases, immunohistochemical reactions were performed to support the primary tumor site. Two cases had a previous histopathological diagnosis of a primary tumor, while for the third case, the metastatic lesion represented the first manifestation of the neoplastic disease, with an unfavorable prognosis. |
| first_indexed | 2024-03-09T01:54:01Z |
| format | Article |
| id | doaj.art-9748ed48541b47f88af91634041a5f66 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T01:54:01Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-9748ed48541b47f88af91634041a5f662023-12-08T15:13:22ZengMDPI AGDiagnostics2075-44182023-11-011323351310.3390/diagnostics13233513Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical ChallengeRaluca-Maria Closca0Adrian Nicoara1Marina Rakitovan2Ion Cristian Mot3Flavia Baderca4Department of Microscopic Morphology, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, RomaniaOro-Maxillo-Facial Surgery Clinic, Emergency City Hospital, 300062 Timisoara, RomaniaOro-Maxillo-Facial Surgery Clinic, Emergency City Hospital, 300062 Timisoara, RomaniaOtorhinolaryngology Clinic, Emergency City Hospital, 300254 Timisoara, RomaniaDepartment of Microscopic Morphology, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, RomaniaMetastatic disease is a complex and sequential process that involves the migration of tumor cells from the primary site to distant areas. This metastatic pathway is not always predictable. Therefore, this paper presents three rare cases of unusual metastases, due to their primary site: two metastases of a clear cell renal cell carcinoma, one gingival, and one nasal, as well as a mandibular metastasis of a hepatocellular carcinoma. In all cases, an incisional biopsy was performed in order to find out the diagnosis. After microscopical examination of morphological Hematoxylin and Eosin-stained slides, for all cases, immunohistochemical reactions were performed to support the primary tumor site. Two cases had a previous histopathological diagnosis of a primary tumor, while for the third case, the metastatic lesion represented the first manifestation of the neoplastic disease, with an unfavorable prognosis.https://www.mdpi.com/2075-4418/13/23/3513head and neckunusual metastasesimmunohistochemistryrenal clear cell carcinomahepatocellular carcinoma |
| spellingShingle | Raluca-Maria Closca Adrian Nicoara Marina Rakitovan Ion Cristian Mot Flavia Baderca Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge Diagnostics head and neck unusual metastases immunohistochemistry renal clear cell carcinoma hepatocellular carcinoma |
| title | Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge |
| title_full | Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge |
| title_fullStr | Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge |
| title_full_unstemmed | Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge |
| title_short | Unpredictable Metastasis in the Head and Neck Region: A Diagnostic Immunohistochemical Challenge |
| title_sort | unpredictable metastasis in the head and neck region a diagnostic immunohistochemical challenge |
| topic | head and neck unusual metastases immunohistochemistry renal clear cell carcinoma hepatocellular carcinoma |
| url | https://www.mdpi.com/2075-4418/13/23/3513 |
| work_keys_str_mv | AT ralucamariaclosca unpredictablemetastasisintheheadandneckregionadiagnosticimmunohistochemicalchallenge AT adriannicoara unpredictablemetastasisintheheadandneckregionadiagnosticimmunohistochemicalchallenge AT marinarakitovan unpredictablemetastasisintheheadandneckregionadiagnosticimmunohistochemicalchallenge AT ioncristianmot unpredictablemetastasisintheheadandneckregionadiagnosticimmunohistochemicalchallenge AT flaviabaderca unpredictablemetastasisintheheadandneckregionadiagnosticimmunohistochemicalchallenge |