Diagnostic Value of Prolactin and B-Hcg Levels of Vaginal Fluid in Diagnosis of Premature Rupture of Membranes
Introduction: The aim of this study was diagnosis of premature rupture of membranes in suspected patients by measurement of prolactin and B-hCG levels in vaginal washing in order to reduce perinatal mortality and morbidity. Methods: The study included 211 pregnant women who were referred to the emer...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Shahid Sadoughi University of Medical Sciences
2009-10-01
|
| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| Subjects: | |
| Online Access: | http://85.185.157.11:6280/jssu/browse.php?a_id=500&slc_lang=en&sid=1&ftxt=1 |
| _version_ | 1818690686896046080 |
|---|---|
| author | M Hoseini N Khoda Karami A Entezari Z Davoodi R Taheri Panah |
| author_facet | M Hoseini N Khoda Karami A Entezari Z Davoodi R Taheri Panah |
| author_sort | M Hoseini |
| collection | DOAJ |
| description | Introduction: The aim of this study was diagnosis of premature rupture of membranes in suspected patients by measurement of prolactin and B-hCG levels in vaginal washing in order to reduce perinatal mortality and morbidity. Methods: The study included 211 pregnant women who were referred to the emergency of Imam Hossein hospital at 28-38 weeks of pregnancy for leakage or prenatal care from April, 2007 to April, 2008. The expulsion of fluid from the cervix was evaluated and fern and nitrazin tests were done. B-hCG and prolactin levels of vaginal washing fluid were measured. The presence of 2 of 3 parameters of fern test, nitrazin and cervical fluid was defined as absolutely premature rupture of membranes. Mann-Withney U-test was used for analysis. The Roc curve was calculated. Results: There were 132 patients in PROM group and79 patient in the control group. The average age in the PROM and control groups was 26.9±6.08 and 26.2±4.84 years, respectively(P=0.074). Both groups were matched for parity and gravidity. Prolactin levels in PROM group were 2930±3737mIU/l versus 23.18±120mIU/l in the control group (P=0.000). B-hCG was 439.78±1867mIU/l in PROM and 17.72±30mIU/l in control group (p=0.000). Sensitivity and specificity of prolactin according to cut-off of 16.0 mIU/l was 79.41% and 96%, respectively. Sensitivity and specificity for B-hCG with cut-off point of 12.5 was 69.85% and 69.33%, respectively. Conclusion: The measurement of prolactin and B-hCG levels in patients with suspected premature rupture of membranes can help in decision-making and treatment. |
| first_indexed | 2024-12-17T12:29:57Z |
| format | Article |
| id | doaj.art-9748f6b765624c69ac53a30c44a44a89 |
| institution | Directory Open Access Journal |
| issn | 2228-5741 2228-5733 |
| language | fas |
| last_indexed | 2024-12-17T12:29:57Z |
| publishDate | 2009-10-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj.art-9748f6b765624c69ac53a30c44a44a892022-12-21T21:48:38ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332009-10-01174234241Diagnostic Value of Prolactin and B-Hcg Levels of Vaginal Fluid in Diagnosis of Premature Rupture of MembranesM HoseiniN Khoda KaramiA EntezariZ DavoodiR Taheri PanahIntroduction: The aim of this study was diagnosis of premature rupture of membranes in suspected patients by measurement of prolactin and B-hCG levels in vaginal washing in order to reduce perinatal mortality and morbidity. Methods: The study included 211 pregnant women who were referred to the emergency of Imam Hossein hospital at 28-38 weeks of pregnancy for leakage or prenatal care from April, 2007 to April, 2008. The expulsion of fluid from the cervix was evaluated and fern and nitrazin tests were done. B-hCG and prolactin levels of vaginal washing fluid were measured. The presence of 2 of 3 parameters of fern test, nitrazin and cervical fluid was defined as absolutely premature rupture of membranes. Mann-Withney U-test was used for analysis. The Roc curve was calculated. Results: There were 132 patients in PROM group and79 patient in the control group. The average age in the PROM and control groups was 26.9±6.08 and 26.2±4.84 years, respectively(P=0.074). Both groups were matched for parity and gravidity. Prolactin levels in PROM group were 2930±3737mIU/l versus 23.18±120mIU/l in the control group (P=0.000). B-hCG was 439.78±1867mIU/l in PROM and 17.72±30mIU/l in control group (p=0.000). Sensitivity and specificity of prolactin according to cut-off of 16.0 mIU/l was 79.41% and 96%, respectively. Sensitivity and specificity for B-hCG with cut-off point of 12.5 was 69.85% and 69.33%, respectively. Conclusion: The measurement of prolactin and B-hCG levels in patients with suspected premature rupture of membranes can help in decision-making and treatment.http://85.185.157.11:6280/jssu/browse.php?a_id=500&slc_lang=en&sid=1&ftxt=1Premature rupture of membranesProlactinB-hCGFern testNitrazin |
| spellingShingle | M Hoseini N Khoda Karami A Entezari Z Davoodi R Taheri Panah Diagnostic Value of Prolactin and B-Hcg Levels of Vaginal Fluid in Diagnosis of Premature Rupture of Membranes Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd Premature rupture of membranes Prolactin B-hCG Fern test Nitrazin |
| title | Diagnostic Value of Prolactin and B-Hcg Levels of Vaginal Fluid in Diagnosis of Premature Rupture of Membranes |
| title_full | Diagnostic Value of Prolactin and B-Hcg Levels of Vaginal Fluid in Diagnosis of Premature Rupture of Membranes |
| title_fullStr | Diagnostic Value of Prolactin and B-Hcg Levels of Vaginal Fluid in Diagnosis of Premature Rupture of Membranes |
| title_full_unstemmed | Diagnostic Value of Prolactin and B-Hcg Levels of Vaginal Fluid in Diagnosis of Premature Rupture of Membranes |
| title_short | Diagnostic Value of Prolactin and B-Hcg Levels of Vaginal Fluid in Diagnosis of Premature Rupture of Membranes |
| title_sort | diagnostic value of prolactin and b hcg levels of vaginal fluid in diagnosis of premature rupture of membranes |
| topic | Premature rupture of membranes Prolactin B-hCG Fern test Nitrazin |
| url | http://85.185.157.11:6280/jssu/browse.php?a_id=500&slc_lang=en&sid=1&ftxt=1 |
| work_keys_str_mv | AT mhoseini diagnosticvalueofprolactinandbhcglevelsofvaginalfluidindiagnosisofprematureruptureofmembranes AT nkhodakarami diagnosticvalueofprolactinandbhcglevelsofvaginalfluidindiagnosisofprematureruptureofmembranes AT aentezari diagnosticvalueofprolactinandbhcglevelsofvaginalfluidindiagnosisofprematureruptureofmembranes AT zdavoodi diagnosticvalueofprolactinandbhcglevelsofvaginalfluidindiagnosisofprematureruptureofmembranes AT rtaheripanah diagnosticvalueofprolactinandbhcglevelsofvaginalfluidindiagnosisofprematureruptureofmembranes |