MOUSE VISION AS A GATEWAY FOR UNDERSTANDING HOW EXPERIENCE SHAPES NEURAL CIRCUITS
Genetic programs controlling ontogeny drive many of the essential connectivity patterns within the brain. Yet it is activity, derived from the experience of interacting with the world, that sculpts the precise circuitry of the central nervous system. Such experience-dependent plasticity has been obs...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00123/full |
| _version_ | 1818139925065760768 |
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| author | Nicholas ePriebe Aaron W McGee |
| author_facet | Nicholas ePriebe Aaron W McGee |
| author_sort | Nicholas ePriebe |
| collection | DOAJ |
| description | Genetic programs controlling ontogeny drive many of the essential connectivity patterns within the brain. Yet it is activity, derived from the experience of interacting with the world, that sculpts the precise circuitry of the central nervous system. Such experience-dependent plasticity has been observed throughout the brain but has been most extensively studied in the neocortex. A prime example of this refinement of neural circuitry is found in primary visual cortex (V1), where functional connectivity changes have been observed both during development and in adulthood. The mouse visual system has become a predominant model for investigating the principles that underlie experience-dependent plasticity, given the general conservation of visual neural circuitry across mammals as well as the powerful tools and techniques recently developed for use in rodent. The genetic tractability of mice has permitted the identification of signaling pathways that translate experience-driven activity patterns into changes in circuitry. Further, the accessibility of visual cortex has allowed neural activity to be manipulated with optogenetics and observed with genetically-encoded calcium sensors. Consequently, mouse visual cortex has become one of the dominant platforms to study experience-dependent plasticity. |
| first_indexed | 2024-12-11T10:35:50Z |
| format | Article |
| id | doaj.art-974926e0cf8d4e44b5f764de3de60e07 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-11T10:35:50Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-974926e0cf8d4e44b5f764de3de60e072022-12-22T01:10:43ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102014-10-01810.3389/fncir.2014.00123112170MOUSE VISION AS A GATEWAY FOR UNDERSTANDING HOW EXPERIENCE SHAPES NEURAL CIRCUITSNicholas ePriebe0Aaron W McGee1The University of Texas at AustinUniversity of Southern CaliforniaGenetic programs controlling ontogeny drive many of the essential connectivity patterns within the brain. Yet it is activity, derived from the experience of interacting with the world, that sculpts the precise circuitry of the central nervous system. Such experience-dependent plasticity has been observed throughout the brain but has been most extensively studied in the neocortex. A prime example of this refinement of neural circuitry is found in primary visual cortex (V1), where functional connectivity changes have been observed both during development and in adulthood. The mouse visual system has become a predominant model for investigating the principles that underlie experience-dependent plasticity, given the general conservation of visual neural circuitry across mammals as well as the powerful tools and techniques recently developed for use in rodent. The genetic tractability of mice has permitted the identification of signaling pathways that translate experience-driven activity patterns into changes in circuitry. Further, the accessibility of visual cortex has allowed neural activity to be manipulated with optogenetics and observed with genetically-encoded calcium sensors. Consequently, mouse visual cortex has become one of the dominant platforms to study experience-dependent plasticity.http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00123/fullVisual Cortexdevelopmentinhibitionocular dominance plasticitybinocularity |
| spellingShingle | Nicholas ePriebe Aaron W McGee MOUSE VISION AS A GATEWAY FOR UNDERSTANDING HOW EXPERIENCE SHAPES NEURAL CIRCUITS Frontiers in Neural Circuits Visual Cortex development inhibition ocular dominance plasticity binocularity |
| title | MOUSE VISION AS A GATEWAY FOR UNDERSTANDING HOW EXPERIENCE SHAPES NEURAL CIRCUITS |
| title_full | MOUSE VISION AS A GATEWAY FOR UNDERSTANDING HOW EXPERIENCE SHAPES NEURAL CIRCUITS |
| title_fullStr | MOUSE VISION AS A GATEWAY FOR UNDERSTANDING HOW EXPERIENCE SHAPES NEURAL CIRCUITS |
| title_full_unstemmed | MOUSE VISION AS A GATEWAY FOR UNDERSTANDING HOW EXPERIENCE SHAPES NEURAL CIRCUITS |
| title_short | MOUSE VISION AS A GATEWAY FOR UNDERSTANDING HOW EXPERIENCE SHAPES NEURAL CIRCUITS |
| title_sort | mouse vision as a gateway for understanding how experience shapes neural circuits |
| topic | Visual Cortex development inhibition ocular dominance plasticity binocularity |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00123/full |
| work_keys_str_mv | AT nicholasepriebe mousevisionasagatewayforunderstandinghowexperienceshapesneuralcircuits AT aaronwmcgee mousevisionasagatewayforunderstandinghowexperienceshapesneuralcircuits |