Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population
Background: Obesity is a well-established risk factor for large artery atherosclerotic (LAA) stroke. The aim of the study was to explore whether obesity genes, such as MC4R and FTO, contribute to LAA stroke risk in the Chinese Han population. Methods: 322 LAA stroke patients and 473 controls were re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2016-10-01
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| Series: | Obesity Facts |
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| Online Access: | http://www.karger.com/Article/FullText/448588 |
| _version_ | 1818921766736625664 |
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| author | Zhi Song Lingling Qiu Zhongyang Hu Jia Liu Ding Liu Deren Hou |
| author_facet | Zhi Song Lingling Qiu Zhongyang Hu Jia Liu Ding Liu Deren Hou |
| author_sort | Zhi Song |
| collection | DOAJ |
| description | Background: Obesity is a well-established risk factor for large artery atherosclerotic (LAA) stroke. The aim of the study was to explore whether obesity genes, such as MC4R and FTO, contribute to LAA stroke risk in the Chinese Han population. Methods: 322 LAA stroke patients and 473 controls were recruited. Gene polymorphism of MC4R (rs17782313) and FTO (rs8050136 and rs9939609) were genotyped. Results: No differences were observed in genotype frequencies of variants of FTO (rs8050136 and rs9939609) or MC4R (rs17782313) between LAA stroke patients and control subjects. However, rs17782313 of the MC4R gene was associated with LAA stroke susceptibility in smokers (rs17782313: p = 0.020, OR (95% CI) = 1.55 (1.07-2.23)) in the stratified analysis. Furthermore, multifactor dimensionality reduction analysis revealed that the combination of MC4R variant (rs17782313), hypertension and smoking habit was significantly associated with increased risk of LAA stroke (p Conclusion: Our study indicated that the synergistic effects of MC4R variants, hypertension, and smoking habit contribute significantly to the risk of LAA stroke in the Chinese Han population. The finding revealed that obesity gene MC4R contribute to the risk of LAA stroke via a synergistic mechanism, which will provide new insight into the genetic architecture of LAA stroke. |
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| id | doaj.art-9749400e9c0d47a3be8c35a45b5759a2 |
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| issn | 1662-4025 1662-4033 |
| language | English |
| last_indexed | 2024-12-20T01:42:52Z |
| publishDate | 2016-10-01 |
| publisher | Karger Publishers |
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| series | Obesity Facts |
| spelling | doaj.art-9749400e9c0d47a3be8c35a45b5759a22022-12-21T19:57:50ZengKarger PublishersObesity Facts1662-40251662-40332016-10-019535336210.1159/000448588448588Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese PopulationZhi SongLingling QiuZhongyang HuJia LiuDing LiuDeren HouBackground: Obesity is a well-established risk factor for large artery atherosclerotic (LAA) stroke. The aim of the study was to explore whether obesity genes, such as MC4R and FTO, contribute to LAA stroke risk in the Chinese Han population. Methods: 322 LAA stroke patients and 473 controls were recruited. Gene polymorphism of MC4R (rs17782313) and FTO (rs8050136 and rs9939609) were genotyped. Results: No differences were observed in genotype frequencies of variants of FTO (rs8050136 and rs9939609) or MC4R (rs17782313) between LAA stroke patients and control subjects. However, rs17782313 of the MC4R gene was associated with LAA stroke susceptibility in smokers (rs17782313: p = 0.020, OR (95% CI) = 1.55 (1.07-2.23)) in the stratified analysis. Furthermore, multifactor dimensionality reduction analysis revealed that the combination of MC4R variant (rs17782313), hypertension and smoking habit was significantly associated with increased risk of LAA stroke (p Conclusion: Our study indicated that the synergistic effects of MC4R variants, hypertension, and smoking habit contribute significantly to the risk of LAA stroke in the Chinese Han population. The finding revealed that obesity gene MC4R contribute to the risk of LAA stroke via a synergistic mechanism, which will provide new insight into the genetic architecture of LAA stroke.http://www.karger.com/Article/FullText/448588FTOMC4RObesity prone geneLarge artery atherosclerotic (LAA) strokeGenetic risk factorSynergistic effect |
| spellingShingle | Zhi Song Lingling Qiu Zhongyang Hu Jia Liu Ding Liu Deren Hou Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population Obesity Facts FTO MC4R Obesity prone gene Large artery atherosclerotic (LAA) stroke Genetic risk factor Synergistic effect |
| title | Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population |
| title_full | Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population |
| title_fullStr | Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population |
| title_full_unstemmed | Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population |
| title_short | Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population |
| title_sort | evaluation of the obesity genes fto and mc4r for contribution to the risk of large artery atherosclerotic stroke in a chinese population |
| topic | FTO MC4R Obesity prone gene Large artery atherosclerotic (LAA) stroke Genetic risk factor Synergistic effect |
| url | http://www.karger.com/Article/FullText/448588 |
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