Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance
Abstract Background A glymphatic system has been proposed that comprises flow that enters along cerebral paraarterial channels between the artery wall and the surrounding glial layer, continues through the parenchyma, and then exits along similar paravenous channels. The mechanism driving flow throu...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Fluids and Barriers of the CNS |
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| Online Access: | https://doi.org/10.1186/s12987-023-00445-0 |
| _version_ | 1797806589862739968 |
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| author | M. Keith Sharp |
| author_facet | M. Keith Sharp |
| author_sort | M. Keith Sharp |
| collection | DOAJ |
| description | Abstract Background A glymphatic system has been proposed that comprises flow that enters along cerebral paraarterial channels between the artery wall and the surrounding glial layer, continues through the parenchyma, and then exits along similar paravenous channels. The mechanism driving flow through this system is unclear. The pulsatile (oscillatory plus mean) flow measured in the space surrounding the middle cerebral artery (MCA) suggests that peristalsis created by intravascular blood pressure pulses is a candidate for the paraarterial flow in the subarachnoid spaces. However, peristalsis is ineffective in driving significant mean flow when the amplitude of channel wall motion is small, as has been observed in the MCA artery wall. In this paper, peristalsis in combination with two additional mechanisms, a longitudinal pressure gradient and directional flow resistance, is evaluated to match the measured MCA paraarterial oscillatory and mean flows. Methods Two analytical models are used that simplify the paraarterial branched network to a long continuous channel with a traveling wave in order to maximize the potential effect of peristalsis on the mean flow. The two models have parallel-plate and annulus geometries, respectively, with and without an added longitudinal pressure gradient. The effect of directional flow resistors was also evaluated for the parallel-plate geometry. Results For these models, the measured amplitude of arterial wall motion is too large to cause the small measured amplitude of oscillatory velocity, indicating that the outer wall must also move. At a combined motion matching the measured oscillatory velocity, peristalsis is incapable of driving enough mean flow. Directional flow resistance elements augment the mean flow, but not enough to provide a match. With a steady longitudinal pressure gradient, both oscillatory and mean flows can be matched to the measurements. Conclusions These results suggest that peristalsis drives the oscillatory flow in the subarachnoid paraarterial space, but is incapable of driving the mean flow. The effect of directional flow resistors is insufficient to produce a match, but a small longitudinal pressure gradient is capable of creating the mean flow. Additional experiments are needed to confirm whether the outer wall also moves, as well as to validate the pressure gradient. |
| first_indexed | 2024-03-13T06:09:34Z |
| format | Article |
| id | doaj.art-974a7b4fb1f04b4483d4324e19b95902 |
| institution | Directory Open Access Journal |
| issn | 2045-8118 |
| language | English |
| last_indexed | 2024-03-13T06:09:34Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Fluids and Barriers of the CNS |
| spelling | doaj.art-974a7b4fb1f04b4483d4324e19b959022023-06-11T11:23:01ZengBMCFluids and Barriers of the CNS2045-81182023-06-012011910.1186/s12987-023-00445-0Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistanceM. Keith Sharp0Department of Mechanical Engineering, University of LouisvilleAbstract Background A glymphatic system has been proposed that comprises flow that enters along cerebral paraarterial channels between the artery wall and the surrounding glial layer, continues through the parenchyma, and then exits along similar paravenous channels. The mechanism driving flow through this system is unclear. The pulsatile (oscillatory plus mean) flow measured in the space surrounding the middle cerebral artery (MCA) suggests that peristalsis created by intravascular blood pressure pulses is a candidate for the paraarterial flow in the subarachnoid spaces. However, peristalsis is ineffective in driving significant mean flow when the amplitude of channel wall motion is small, as has been observed in the MCA artery wall. In this paper, peristalsis in combination with two additional mechanisms, a longitudinal pressure gradient and directional flow resistance, is evaluated to match the measured MCA paraarterial oscillatory and mean flows. Methods Two analytical models are used that simplify the paraarterial branched network to a long continuous channel with a traveling wave in order to maximize the potential effect of peristalsis on the mean flow. The two models have parallel-plate and annulus geometries, respectively, with and without an added longitudinal pressure gradient. The effect of directional flow resistors was also evaluated for the parallel-plate geometry. Results For these models, the measured amplitude of arterial wall motion is too large to cause the small measured amplitude of oscillatory velocity, indicating that the outer wall must also move. At a combined motion matching the measured oscillatory velocity, peristalsis is incapable of driving enough mean flow. Directional flow resistance elements augment the mean flow, but not enough to provide a match. With a steady longitudinal pressure gradient, both oscillatory and mean flows can be matched to the measurements. Conclusions These results suggest that peristalsis drives the oscillatory flow in the subarachnoid paraarterial space, but is incapable of driving the mean flow. The effect of directional flow resistors is insufficient to produce a match, but a small longitudinal pressure gradient is capable of creating the mean flow. Additional experiments are needed to confirm whether the outer wall also moves, as well as to validate the pressure gradient.https://doi.org/10.1186/s12987-023-00445-0BrainGlymphatic flowPeristaltic flowPerivascularParavascular |
| spellingShingle | M. Keith Sharp Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance Fluids and Barriers of the CNS Brain Glymphatic flow Peristaltic flow Perivascular Paravascular |
| title | Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance |
| title_full | Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance |
| title_fullStr | Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance |
| title_full_unstemmed | Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance |
| title_short | Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance |
| title_sort | pulsatile cerebral paraarterial flow by peristalsis pressure and directional resistance |
| topic | Brain Glymphatic flow Peristaltic flow Perivascular Paravascular |
| url | https://doi.org/10.1186/s12987-023-00445-0 |
| work_keys_str_mv | AT mkeithsharp pulsatilecerebralparaarterialflowbyperistalsispressureanddirectionalresistance |