Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila

Even in well-studied species, there is still substantial natural genetic variation that has not been characterized. Here, the authors use long read sequencing to discover transposable elements in the Drosophila genome not detected by short read sequencing, and link them to gene expression.

Bibliographic Details
Main Authors: Gabriel E. Rech, Santiago Radío, Sara Guirao-Rico, Laura Aguilera, Vivien Horvath, Llewellyn Green, Hannah Lindstadt, Véronique Jamilloux, Hadi Quesneville, Josefa González
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29518-8
_version_ 1818022480465362944
author Gabriel E. Rech
Santiago Radío
Sara Guirao-Rico
Laura Aguilera
Vivien Horvath
Llewellyn Green
Hannah Lindstadt
Véronique Jamilloux
Hadi Quesneville
Josefa González
author_facet Gabriel E. Rech
Santiago Radío
Sara Guirao-Rico
Laura Aguilera
Vivien Horvath
Llewellyn Green
Hannah Lindstadt
Véronique Jamilloux
Hadi Quesneville
Josefa González
author_sort Gabriel E. Rech
collection DOAJ
description Even in well-studied species, there is still substantial natural genetic variation that has not been characterized. Here, the authors use long read sequencing to discover transposable elements in the Drosophila genome not detected by short read sequencing, and link them to gene expression.
first_indexed 2024-04-14T08:32:17Z
format Article
id doaj.art-974aeaeb89bd46518065ccb417e58235
institution Directory Open Access Journal
issn 2041-1723
language English
last_indexed 2024-04-14T08:32:17Z
publishDate 2022-04-01
publisher Nature Portfolio
record_format Article
series Nature Communications
spelling doaj.art-974aeaeb89bd46518065ccb417e582352022-12-22T02:03:52ZengNature PortfolioNature Communications2041-17232022-04-0113111610.1038/s41467-022-29518-8Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in DrosophilaGabriel E. Rech0Santiago Radío1Sara Guirao-Rico2Laura Aguilera3Vivien Horvath4Llewellyn Green5Hannah Lindstadt6Véronique Jamilloux7Hadi Quesneville8Josefa González9Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)Université Paris-Saclay, INRAE, URGIUniversité Paris-Saclay, INRAE, URGIInstitute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)Even in well-studied species, there is still substantial natural genetic variation that has not been characterized. Here, the authors use long read sequencing to discover transposable elements in the Drosophila genome not detected by short read sequencing, and link them to gene expression.https://doi.org/10.1038/s41467-022-29518-8
spellingShingle Gabriel E. Rech
Santiago Radío
Sara Guirao-Rico
Laura Aguilera
Vivien Horvath
Llewellyn Green
Hannah Lindstadt
Véronique Jamilloux
Hadi Quesneville
Josefa González
Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila
Nature Communications
title Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila
title_full Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila
title_fullStr Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila
title_full_unstemmed Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila
title_short Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila
title_sort population scale long read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in drosophila
url https://doi.org/10.1038/s41467-022-29518-8
work_keys_str_mv AT gabrielerech populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT santiagoradio populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT saraguiraorico populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT lauraaguilera populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT vivienhorvath populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT llewellyngreen populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT hannahlindstadt populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT veroniquejamilloux populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT hadiquesneville populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila
AT josefagonzalez populationscalelongreadsequencinguncoverstransposableelementsassociatedwithgeneexpressionvariationandadaptivesignaturesindrosophila