Importance of Clinical Isolates in <i>Cryptococcus neoformans</i> Research
The human pathogenic fungus <i>Cryptococcus neoformans</i> is a global health concern. Previous research in the field has focused on studies using reference strains to identify virulence factors, generate mutant libraries, define genomic structures, and perform functional studies. In thi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/9/3/364 |
| _version_ | 1827749190154846208 |
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| author | Katrina M. Jackson Minna Ding Kirsten Nielsen |
| author_facet | Katrina M. Jackson Minna Ding Kirsten Nielsen |
| author_sort | Katrina M. Jackson |
| collection | DOAJ |
| description | The human pathogenic fungus <i>Cryptococcus neoformans</i> is a global health concern. Previous research in the field has focused on studies using reference strains to identify virulence factors, generate mutant libraries, define genomic structures, and perform functional studies. In this review, we discuss the benefits and drawbacks of using reference strains to study <i>C. neoformans</i>, describe how the study of clinical isolates has expanded our understanding of pathogenesis, and highlight how studies using clinical isolates can further develop our understanding of the host–pathogen interaction during <i>C. neoformans</i> infection. |
| first_indexed | 2024-03-11T06:20:19Z |
| format | Article |
| id | doaj.art-974e009948fb48e38f974c34d6d88e1a |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-11T06:20:19Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-974e009948fb48e38f974c34d6d88e1a2023-11-17T12:00:32ZengMDPI AGJournal of Fungi2309-608X2023-03-019336410.3390/jof9030364Importance of Clinical Isolates in <i>Cryptococcus neoformans</i> ResearchKatrina M. Jackson0Minna Ding1Kirsten Nielsen2Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USADepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USADepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USAThe human pathogenic fungus <i>Cryptococcus neoformans</i> is a global health concern. Previous research in the field has focused on studies using reference strains to identify virulence factors, generate mutant libraries, define genomic structures, and perform functional studies. In this review, we discuss the benefits and drawbacks of using reference strains to study <i>C. neoformans</i>, describe how the study of clinical isolates has expanded our understanding of pathogenesis, and highlight how studies using clinical isolates can further develop our understanding of the host–pathogen interaction during <i>C. neoformans</i> infection.https://www.mdpi.com/2309-608X/9/3/364<i>Cryptococcus neoformans</i>clinical isolateshost–pathogen interactiongenotype |
| spellingShingle | Katrina M. Jackson Minna Ding Kirsten Nielsen Importance of Clinical Isolates in <i>Cryptococcus neoformans</i> Research Journal of Fungi <i>Cryptococcus neoformans</i> clinical isolates host–pathogen interaction genotype |
| title | Importance of Clinical Isolates in <i>Cryptococcus neoformans</i> Research |
| title_full | Importance of Clinical Isolates in <i>Cryptococcus neoformans</i> Research |
| title_fullStr | Importance of Clinical Isolates in <i>Cryptococcus neoformans</i> Research |
| title_full_unstemmed | Importance of Clinical Isolates in <i>Cryptococcus neoformans</i> Research |
| title_short | Importance of Clinical Isolates in <i>Cryptococcus neoformans</i> Research |
| title_sort | importance of clinical isolates in i cryptococcus neoformans i research |
| topic | <i>Cryptococcus neoformans</i> clinical isolates host–pathogen interaction genotype |
| url | https://www.mdpi.com/2309-608X/9/3/364 |
| work_keys_str_mv | AT katrinamjackson importanceofclinicalisolatesinicryptococcusneoformansiresearch AT minnading importanceofclinicalisolatesinicryptococcusneoformansiresearch AT kirstennielsen importanceofclinicalisolatesinicryptococcusneoformansiresearch |