Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study
Background Several studies have reported that depression is prevalent in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (DKD). Methods From the Korean Natio...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2023-01-01
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| Series: | Kidney Research and Clinical Practice |
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| Online Access: | http://krcp-ksn.org/upload/pdf/j-krcp-21-294.pdf |
| _version_ | 1797821929701244928 |
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| author | Hong Sang Choi Bongseong Kim Kyung-Do Han Tae Ryom Oh Sang Heon Suh Minah Kim Chang Seong Kim Eun Hui Bae Seong Kwon Ma Soo Wan Kim |
| author_facet | Hong Sang Choi Bongseong Kim Kyung-Do Han Tae Ryom Oh Sang Heon Suh Minah Kim Chang Seong Kim Eun Hui Bae Seong Kwon Ma Soo Wan Kim |
| author_sort | Hong Sang Choi |
| collection | DOAJ |
| description | Background Several studies have reported that depression is prevalent in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (DKD). Methods From the Korean National Health Insurance Service database, we selected 67,866 patients with DKD and body weight data from two consecutive health examinations with a 2-year interval between 2009 and 2012. Weight change over 2 years was categorized into five groups: ≥–10%, <–10% to ≥–5%, <–5% to <5%, ≥5% to <10%, and ≥10%. The occurrence of depression was monitored via the codes of International Statistical Classification of Diseases, 10th revision through the end of 2018. Results During the 5.24-year follow-up, 17,023 patients with DKD developed depression. Weight change and the risk of depression had a U-shaped relationship: patients with ≥–10% weight change (hazard ratio [HR], 1.12) and those with ≥10% weight change (HR, 1.11) showed higher HRs for depression than those with <–5% to <5% weight change, even after adjusting for several confounding factors. In the subgroup analyses, the risk of depression tended to increase as weight gain or weight loss increased in all subgroups. Conclusion Both weight loss and weight gain increased the risk of depression in patients with DKD. |
| first_indexed | 2024-03-13T09:59:56Z |
| format | Article |
| id | doaj.art-974e250c04ef450dad34d46437b6d2ca |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-03-13T09:59:56Z |
| publishDate | 2023-01-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-974e250c04ef450dad34d46437b6d2ca2023-05-23T06:12:37ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402023-01-01421869710.23876/j.krcp.21.2946170Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based studyHong Sang Choi0Bongseong Kim1Kyung-Do Han2Tae Ryom Oh3Sang Heon Suh4Minah Kim5Chang Seong Kim6Eun Hui Bae7Seong Kwon Ma8Soo Wan Kim9 Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaBackground Several studies have reported that depression is prevalent in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (DKD). Methods From the Korean National Health Insurance Service database, we selected 67,866 patients with DKD and body weight data from two consecutive health examinations with a 2-year interval between 2009 and 2012. Weight change over 2 years was categorized into five groups: ≥–10%, <–10% to ≥–5%, <–5% to <5%, ≥5% to <10%, and ≥10%. The occurrence of depression was monitored via the codes of International Statistical Classification of Diseases, 10th revision through the end of 2018. Results During the 5.24-year follow-up, 17,023 patients with DKD developed depression. Weight change and the risk of depression had a U-shaped relationship: patients with ≥–10% weight change (hazard ratio [HR], 1.12) and those with ≥10% weight change (HR, 1.11) showed higher HRs for depression than those with <–5% to <5% weight change, even after adjusting for several confounding factors. In the subgroup analyses, the risk of depression tended to increase as weight gain or weight loss increased in all subgroups. Conclusion Both weight loss and weight gain increased the risk of depression in patients with DKD.http://krcp-ksn.org/upload/pdf/j-krcp-21-294.pdfdepressiondiabetic nephropathiesriskweight change |
| spellingShingle | Hong Sang Choi Bongseong Kim Kyung-Do Han Tae Ryom Oh Sang Heon Suh Minah Kim Chang Seong Kim Eun Hui Bae Seong Kwon Ma Soo Wan Kim Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study Kidney Research and Clinical Practice depression diabetic nephropathies risk weight change |
| title | Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study |
| title_full | Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study |
| title_fullStr | Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study |
| title_full_unstemmed | Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study |
| title_short | Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study |
| title_sort | weight change and risk of depression in patients with diabetic kidney disease a nationwide population based study |
| topic | depression diabetic nephropathies risk weight change |
| url | http://krcp-ksn.org/upload/pdf/j-krcp-21-294.pdf |
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