Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies
The 15-amino-acid primary immunodominant (PID) region on HIV-1 gp41 adopts an ensemble of conformational states. This conformational plasticity is suggested to misdirect the early humoral immune response.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03235-w |
| _version_ | 1819025022017077248 |
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| author | Jonathan D. Cook Adree Khondker Jeffrey E. Lee |
| author_facet | Jonathan D. Cook Adree Khondker Jeffrey E. Lee |
| author_sort | Jonathan D. Cook |
| collection | DOAJ |
| description | The 15-amino-acid primary immunodominant (PID) region on HIV-1 gp41 adopts an ensemble of conformational states. This conformational plasticity is suggested to misdirect the early humoral immune response. |
| first_indexed | 2024-12-21T05:04:04Z |
| format | Article |
| id | doaj.art-975001eae0044684b2e27e8cb9142fd2 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-21T05:04:04Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-975001eae0044684b2e27e8cb9142fd22022-12-21T19:15:09ZengNature PortfolioCommunications Biology2399-36422022-03-015111310.1038/s42003-022-03235-wConformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodiesJonathan D. Cook0Adree Khondker1Jeffrey E. Lee2Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of TorontoDepartment of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of TorontoDepartment of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of TorontoThe 15-amino-acid primary immunodominant (PID) region on HIV-1 gp41 adopts an ensemble of conformational states. This conformational plasticity is suggested to misdirect the early humoral immune response.https://doi.org/10.1038/s42003-022-03235-w |
| spellingShingle | Jonathan D. Cook Adree Khondker Jeffrey E. Lee Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies Communications Biology |
| title | Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies |
| title_full | Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies |
| title_fullStr | Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies |
| title_full_unstemmed | Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies |
| title_short | Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies |
| title_sort | conformational plasticity of the hiv 1 gp41 immunodominant region is recognized by multiple non neutralizing antibodies |
| url | https://doi.org/10.1038/s42003-022-03235-w |
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