Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies

Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies

The 15-amino-acid primary immunodominant (PID) region on HIV-1 gp41 adopts an ensemble of conformational states. This conformational plasticity is suggested to misdirect the early humoral immune response.

Bibliographic Details
Main Authors:	Jonathan D. Cook, Adree Khondker, Jeffrey E. Lee
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-03-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-022-03235-w

Similar Items

Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.
by: S Moses Dennison, et al.
Published: (2011-01-01)

Neutralizing Antibodies Targeting HIV-1 gp41
by: Christophe Caillat, et al.
Published: (2020-10-01)

Prevalence of antibodies against an immunodominant region of the HIV-1 envelope glycoprotein gp41 in sera from HIV-1 infected individuals in Brazil
by: Vera Bongertz, et al.
Published: (1994-09-01)

Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations.
by: John M Louis, et al.
Published: (2014-01-01)

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies
by: Christophe Caillat, et al.
Published: (2021-04-01)

HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development.
by: Laurent Verkoczy, et al.
Published: (2014-05-01)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
by: Han D, et al.
Published: (2012-09-01)

Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
by: Sonu Kumar, et al.
Published: (2021-06-01)

Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
by: Nika M. Strokappe, et al.
Published: (2019-06-01)

Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein.
by: Mark D Hicar, et al.
Published: (2016-01-01)

Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization.
by: Arthur S Kim, et al.
Published: (2014-07-01)

Cross-reactive Anti-gp41 HIV-1 Neutralizing Human Monoclonal Antibodies Selected by Competitive Panning Against gp140 – an Update
by: Sidorov Igor, et al.
Published: (2005-12-01)

Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity
by: Seth H. Pincus, et al.
Published: (2021-07-01)

Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies.
by: Ben-Jiang Ma, et al.
Published: (2011-09-01)

HIV-1 gp41 core with exposed membrane-proximal external region inducing broad HIV-1 neutralizing antibodies.
by: Ji Wang, et al.
Published: (2011-03-01)

Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41.
by: Catherine A Blish, et al.
Published: (2008-01-01)

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity
by: Julie Prigent, et al.
Published: (2018-05-01)

Lipid Binding: A Necessary Evil for Broadly Neutralizing Anti-gp41 Antibodies?
by: Scherer, E, et al.
Published: (2008)

Analysis of gp41 epitopes in model viral membranes to study HIV-1 neutralization
by: Reichart T, et al.
Published: (2012-09-01)

Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus
by: Mark Smyth, et al.
Published: (2021-06-01)

P04-06. Evolution of an anti-MPER gp41 antibody response that mediates broad HIV-1 cross-neutralization
by: Abdool-Karim S, et al.
Published: (2009-10-01)

Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines.
by: Ling Ye, et al.
Published: (2011-01-01)

Assessing the protective efficacy of antibodies to the HIV gp41 region by active vaccination
by: Sharma SK, et al.
Published: (2012-09-01)

Identification of HIV gp41-specific antibodies that mediate killing of infected cells.
by: Katherine L Williams, et al.
Published: (2019-02-01)

Fully Hydrophobic HIV gp41 Adopts a Hemifusion-Like Conformation in Phospholipid Bilayers
by: Lee, Myungwoon, et al.
Published: (2022)

Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein.
by: Russell Vassell, et al.
Published: (2015-01-01)

Structural plasticity and conformational transitions of HIV envelope glycoprotein gp120.
by: Anil Korkut, et al.
Published: (2012-01-01)

The Gp41 Sequence Connecting Mper and Tm Domains Constitutes a Distinct HIV-1 "Fusion Peptide" Targeted by Neutralizing Antibodies
by: Apellaniz, B, et al.
Published: (2014)

Detection of Novel Neutralizing Antibody Reactivities Against The Membrane Proximal External Region (MPER) of gp41 in HIV-1 Infected Humans
by: Shaw George M
Published: (2005-12-01)

Feeding Eggs from Hens Immunized with Specific KLH-Conjugated HIV Peptide Candidate Vaccines to Chicks Induces Specific Anti-HIV gp120 and gp41 Antibodies that Neutralize the Original HIV Antigens
by: Justiz Vaillant, et al.
Published: (2020-12-01)

Diversification of specificity after maturation of the antibody response to the HIV gp41 epitope ELDKWA.
by: Henry N White, et al.
Published: (2012-01-01)

Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice
by: Milan Kuchař, et al.
Published: (2021-12-01)

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
by: Cirelli, Kimberly M., et al.
Published: (2020)

Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function.
by: Javier Guenaga, et al.
Published: (2012-01-01)

Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds
by: Oakes, V, et al.
Published: (2018)

Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting.
by: Lynn Morris, et al.
Published: (2011-01-01)

Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail
by: Takeo eKuwata, et al.
Published: (2013-05-01)

Conformational Stabilization of Gp41-Mimetic Miniproteins Opens Up New Ways of Inhibiting HIV-1 Fusion
by: Mario Cano-Muñoz, et al.
Published: (2022-03-01)

Identification of a HIV Gp41-Specific Human Monoclonal Antibody With Potent Antibody-Dependent Cellular Cytotoxicity
by: Zheng Yang, et al.
Published: (2018-11-01)

P05-13. Fragments of HIV-1 gp41 derivatives presented on virus-like particles with preserved binding affinity for broadly neutralizing antibodies
by: Wagner R, et al.
Published: (2009-10-01)