Non-Ionizing Millimeter Waves Non-Thermal Radiation of <i>Saccharomyces cerevisiae</i>—Insights and Interactions
Non-ionizing millimeter-waves (MMW) interact with cells in a variety of ways. Here the inhibited cell division effect was investigated using 85–105 GHz MMW irradiation within the International Commission on Non-Ionizing Radiation Protection (ICNIRP) non-thermal 20 mW/cm<sup>2</sup> safet...
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MDPI AG
2021-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/14/6635 |
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| author | Ayan Barbora Shailendra Rajput Konstantin Komoshvili Jacob Levitan Asher Yahalom Stella Liberman-Aronov |
| author_facet | Ayan Barbora Shailendra Rajput Konstantin Komoshvili Jacob Levitan Asher Yahalom Stella Liberman-Aronov |
| author_sort | Ayan Barbora |
| collection | DOAJ |
| description | Non-ionizing millimeter-waves (MMW) interact with cells in a variety of ways. Here the inhibited cell division effect was investigated using 85–105 GHz MMW irradiation within the International Commission on Non-Ionizing Radiation Protection (ICNIRP) non-thermal 20 mW/cm<sup>2</sup> safety standards. Irradiation using a power density of about 1.0 mW/cm<sup>2</sup> SAR over 5–6 h on 50 cells/μL samples of <i>Saccharomyces cerevisiae</i> model organism resulted in 62% growth rate reduction compared to the control (sham). The effect was specific for 85–105 GHz range and was energy- and cell density-dependent. Irradiation of wild type and <i>Δrad52</i> (DNA damage repair gene) deleted cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause permanent genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm<sup>2</sup>) and compared to that of a compact waveguide (17.17 mW/cm<sup>2</sup>) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. We have shown that non-thermal MMW radiation has potential for future use in treatment of yeast related diseases and other targeted biomedical outcomes. |
| first_indexed | 2024-03-10T09:46:07Z |
| format | Article |
| id | doaj.art-97537687a1474315b0c198a90cac42b5 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T09:46:07Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-97537687a1474315b0c198a90cac42b52023-11-22T03:13:07ZengMDPI AGApplied Sciences2076-34172021-07-011114663510.3390/app11146635Non-Ionizing Millimeter Waves Non-Thermal Radiation of <i>Saccharomyces cerevisiae</i>—Insights and InteractionsAyan Barbora0Shailendra Rajput1Konstantin Komoshvili2Jacob Levitan3Asher Yahalom4Stella Liberman-Aronov5Department of Molecular Biology, Ariel University, Ariel 40700, IsraelDepartment of Electrical and Electronic Engineering, Ariel University, Ariel 40700, IsraelDepartment of Physics, Ariel University, Ariel 40700, IsraelDepartment of Physics, Ariel University, Ariel 40700, IsraelDepartment of Electrical and Electronic Engineering, Ariel University, Ariel 40700, IsraelDepartment of Molecular Biology, Ariel University, Ariel 40700, IsraelNon-ionizing millimeter-waves (MMW) interact with cells in a variety of ways. Here the inhibited cell division effect was investigated using 85–105 GHz MMW irradiation within the International Commission on Non-Ionizing Radiation Protection (ICNIRP) non-thermal 20 mW/cm<sup>2</sup> safety standards. Irradiation using a power density of about 1.0 mW/cm<sup>2</sup> SAR over 5–6 h on 50 cells/μL samples of <i>Saccharomyces cerevisiae</i> model organism resulted in 62% growth rate reduction compared to the control (sham). The effect was specific for 85–105 GHz range and was energy- and cell density-dependent. Irradiation of wild type and <i>Δrad52</i> (DNA damage repair gene) deleted cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause permanent genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm<sup>2</sup>) and compared to that of a compact waveguide (17.17 mW/cm<sup>2</sup>) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. We have shown that non-thermal MMW radiation has potential for future use in treatment of yeast related diseases and other targeted biomedical outcomes.https://www.mdpi.com/2076-3417/11/14/6635non-ionizing radiationmillimeter wavesnovel biomedical applicationsyeastnon-invasive devices |
| spellingShingle | Ayan Barbora Shailendra Rajput Konstantin Komoshvili Jacob Levitan Asher Yahalom Stella Liberman-Aronov Non-Ionizing Millimeter Waves Non-Thermal Radiation of <i>Saccharomyces cerevisiae</i>—Insights and Interactions Applied Sciences non-ionizing radiation millimeter waves novel biomedical applications yeast non-invasive devices |
| title | Non-Ionizing Millimeter Waves Non-Thermal Radiation of <i>Saccharomyces cerevisiae</i>—Insights and Interactions |
| title_full | Non-Ionizing Millimeter Waves Non-Thermal Radiation of <i>Saccharomyces cerevisiae</i>—Insights and Interactions |
| title_fullStr | Non-Ionizing Millimeter Waves Non-Thermal Radiation of <i>Saccharomyces cerevisiae</i>—Insights and Interactions |
| title_full_unstemmed | Non-Ionizing Millimeter Waves Non-Thermal Radiation of <i>Saccharomyces cerevisiae</i>—Insights and Interactions |
| title_short | Non-Ionizing Millimeter Waves Non-Thermal Radiation of <i>Saccharomyces cerevisiae</i>—Insights and Interactions |
| title_sort | non ionizing millimeter waves non thermal radiation of i saccharomyces cerevisiae i insights and interactions |
| topic | non-ionizing radiation millimeter waves novel biomedical applications yeast non-invasive devices |
| url | https://www.mdpi.com/2076-3417/11/14/6635 |
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