Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause
Research suggests that adiponectin, leptin, and genetic polymorphisms such as catechol-O-methyltransferase (COMT) genotype may play an integral role in blood pressure status and thereby cardiovascular health. This is an area especially important for women who are post-menopause; however, the current...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679023000757/type/journal_article |
| _version_ | 1827814409763815424 |
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| author | Lauren Green Laura Byham-Gray Mindy Kurzer Hamed Samavat |
| author_facet | Lauren Green Laura Byham-Gray Mindy Kurzer Hamed Samavat |
| author_sort | Lauren Green |
| collection | DOAJ |
| description | Research suggests that adiponectin, leptin, and genetic polymorphisms such as catechol-O-methyltransferase (COMT) genotype may play an integral role in blood pressure status and thereby cardiovascular health. This is an area especially important for women who are post-menopause; however, the current literature investigating these associations is limited. This study was a cross-sectional secondary analysis of baseline data (N 237) from the Minnesota Green Tea Trial (MGTT). The current study explored the relationships between plasma adiponectin, leptin, and COMT genotype on blood pressure measures. Plasma adiponectin and leptin were obtained after an overnight fast of at least 10 h and were measured by the radioimmunoassay method. The relationships were analysed using multiple linear regression after adjusting for potential confounders. Effect modifications by age, body mass index (BMI) category, blood pressure category, antihypertensive medication use, and COMT genotype were also investigated. The majority of participants were non-Hispanic (97⋅9 %) and Caucasian (94⋅9 %). Mean (sd) age and BMI were 60⋅7 (5⋅0) years and 28⋅2 (2⋅9) kg/m2, respectively. After adjustment for confounding variables, neither plasma adiponectin, plasma leptin nor COMT genotype was associated with systolic or diastolic blood pressure measures. The results of stratified analyses also did not reveal any significant interactions or associations. Based on the findings of this study, which utilised more rigorous statistical methods than previous research, neither adiponectin, leptin nor COMT genotype play a role in blood pressure measures in women who are post-menopause. |
| first_indexed | 2024-03-11T23:45:09Z |
| format | Article |
| id | doaj.art-975601e131e846dc98386218c4113979 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-03-11T23:45:09Z |
| publishDate | 2023-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-975601e131e846dc98386218c41139792023-09-19T10:41:45ZengCambridge University PressJournal of Nutritional Science2048-67902023-01-011210.1017/jns.2023.75Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopauseLauren Green0https://orcid.org/0000-0002-4763-4903Laura Byham-Gray1Mindy Kurzer2Hamed Samavat3School of Health Professions, Department of Clinical and Preventive Nutrition Sciences, Rutgers University, Newark, NJ, USASchool of Health Professions, Department of Clinical and Preventive Nutrition Sciences, Rutgers University, Newark, NJ, USADepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USASchool of Health Professions, Department of Clinical and Preventive Nutrition Sciences, Rutgers University, Newark, NJ, USAResearch suggests that adiponectin, leptin, and genetic polymorphisms such as catechol-O-methyltransferase (COMT) genotype may play an integral role in blood pressure status and thereby cardiovascular health. This is an area especially important for women who are post-menopause; however, the current literature investigating these associations is limited. This study was a cross-sectional secondary analysis of baseline data (N 237) from the Minnesota Green Tea Trial (MGTT). The current study explored the relationships between plasma adiponectin, leptin, and COMT genotype on blood pressure measures. Plasma adiponectin and leptin were obtained after an overnight fast of at least 10 h and were measured by the radioimmunoassay method. The relationships were analysed using multiple linear regression after adjusting for potential confounders. Effect modifications by age, body mass index (BMI) category, blood pressure category, antihypertensive medication use, and COMT genotype were also investigated. The majority of participants were non-Hispanic (97⋅9 %) and Caucasian (94⋅9 %). Mean (sd) age and BMI were 60⋅7 (5⋅0) years and 28⋅2 (2⋅9) kg/m2, respectively. After adjustment for confounding variables, neither plasma adiponectin, plasma leptin nor COMT genotype was associated with systolic or diastolic blood pressure measures. The results of stratified analyses also did not reveal any significant interactions or associations. Based on the findings of this study, which utilised more rigorous statistical methods than previous research, neither adiponectin, leptin nor COMT genotype play a role in blood pressure measures in women who are post-menopause.https://www.cambridge.org/core/product/identifier/S2048679023000757/type/journal_articleAdiponectinBlood pressureCOMT genotypeDiastolic blood pressureLeptinSystolic blood pressure |
| spellingShingle | Lauren Green Laura Byham-Gray Mindy Kurzer Hamed Samavat Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause Journal of Nutritional Science Adiponectin Blood pressure COMT genotype Diastolic blood pressure Leptin Systolic blood pressure |
| title | Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause |
| title_full | Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause |
| title_fullStr | Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause |
| title_full_unstemmed | Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause |
| title_short | Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause |
| title_sort | exploration of plasma adiponectin leptin and comt genotype on blood pressure among women who are post menopause |
| topic | Adiponectin Blood pressure COMT genotype Diastolic blood pressure Leptin Systolic blood pressure |
| url | https://www.cambridge.org/core/product/identifier/S2048679023000757/type/journal_article |
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