Altered low-frequency brain rhythms precede changes in gamma power during tauopathy
Summary: Neurodegenerative disorders are associated with widespread disruption to brain activity and brain rhythms. Some disorders are linked to dysfunction of the membrane-associated protein Tau. Here, we ask how brain rhythms are affected in rTg4510 mouse model of tauopathy, at an early stage of t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222015048 |
| _version_ | 1817985462808084480 |
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| author | Fabio R. Rodrigues Amalia Papanikolaou Joanna Holeniewska Keith G. Phillips Aman B. Saleem Samuel G. Solomon |
| author_facet | Fabio R. Rodrigues Amalia Papanikolaou Joanna Holeniewska Keith G. Phillips Aman B. Saleem Samuel G. Solomon |
| author_sort | Fabio R. Rodrigues |
| collection | DOAJ |
| description | Summary: Neurodegenerative disorders are associated with widespread disruption to brain activity and brain rhythms. Some disorders are linked to dysfunction of the membrane-associated protein Tau. Here, we ask how brain rhythms are affected in rTg4510 mouse model of tauopathy, at an early stage of tauopathy (5 months), and at a more advanced stage (8 months). We measured brain rhythms in primary visual cortex in presence or absence of visual stimulation, while monitoring pupil diameter and locomotion to establish behavioral state. At 5 months, we found increased low-frequency rhythms during resting state in tauopathic animals, associated with periods of abnormally increased neural synchronization. At 8 months, this increase in low-frequency rhythms was accompanied by a reduction of power in the gamma range. Our results therefore show that slower rhythms are impaired earlier than gamma rhythms in this model of tauopathy, and suggest that electrophysiological measurements can track the progression of tauopathic neurodegeneration. |
| first_indexed | 2024-04-13T23:58:29Z |
| format | Article |
| id | doaj.art-975606e78aa34cbea95f34532edc521e |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-13T23:58:29Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-975606e78aa34cbea95f34532edc521e2022-12-22T02:23:48ZengElsevieriScience2589-00422022-10-012510105232Altered low-frequency brain rhythms precede changes in gamma power during tauopathyFabio R. Rodrigues0Amalia Papanikolaou1Joanna Holeniewska2Keith G. Phillips3Aman B. Saleem4Samuel G. Solomon5UCL Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London, London WC1H 0AP, UK; Corresponding authorUCL Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London, London WC1H 0AP, UKUCL Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London, London WC1H 0AP, UKEli Lilly, Research and Development, Erl Wood, Surrey GU20 6PH, UKUCL Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London, London WC1H 0AP, UKUCL Institute of Behavioural Neuroscience, Department of Experimental Psychology, University College London, London WC1H 0AP, UKSummary: Neurodegenerative disorders are associated with widespread disruption to brain activity and brain rhythms. Some disorders are linked to dysfunction of the membrane-associated protein Tau. Here, we ask how brain rhythms are affected in rTg4510 mouse model of tauopathy, at an early stage of tauopathy (5 months), and at a more advanced stage (8 months). We measured brain rhythms in primary visual cortex in presence or absence of visual stimulation, while monitoring pupil diameter and locomotion to establish behavioral state. At 5 months, we found increased low-frequency rhythms during resting state in tauopathic animals, associated with periods of abnormally increased neural synchronization. At 8 months, this increase in low-frequency rhythms was accompanied by a reduction of power in the gamma range. Our results therefore show that slower rhythms are impaired earlier than gamma rhythms in this model of tauopathy, and suggest that electrophysiological measurements can track the progression of tauopathic neurodegeneration.http://www.sciencedirect.com/science/article/pii/S2589004222015048Biological sciencesNeuroscienceClinical neuroscienceCognitive neuroscience |
| spellingShingle | Fabio R. Rodrigues Amalia Papanikolaou Joanna Holeniewska Keith G. Phillips Aman B. Saleem Samuel G. Solomon Altered low-frequency brain rhythms precede changes in gamma power during tauopathy iScience Biological sciences Neuroscience Clinical neuroscience Cognitive neuroscience |
| title | Altered low-frequency brain rhythms precede changes in gamma power during tauopathy |
| title_full | Altered low-frequency brain rhythms precede changes in gamma power during tauopathy |
| title_fullStr | Altered low-frequency brain rhythms precede changes in gamma power during tauopathy |
| title_full_unstemmed | Altered low-frequency brain rhythms precede changes in gamma power during tauopathy |
| title_short | Altered low-frequency brain rhythms precede changes in gamma power during tauopathy |
| title_sort | altered low frequency brain rhythms precede changes in gamma power during tauopathy |
| topic | Biological sciences Neuroscience Clinical neuroscience Cognitive neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222015048 |
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