T cell/histiocyte rich B-cell lymphoma: A difficult diagnosis to make
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Rarely, DLBCL appears on a background of T-cell and histiocyte-rich stroma, referred to as T-cell/histiocyte rich large B cell lymphoma (T/HRBCL). It is distinguished by its aggressive clinical course and high rat...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621920300417 |
| _version_ | 1818692675459612672 |
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| author | Olutayo A. Sogunro Rachael Steinhauer Eugene Lewis |
| author_facet | Olutayo A. Sogunro Rachael Steinhauer Eugene Lewis |
| author_sort | Olutayo A. Sogunro |
| collection | DOAJ |
| description | Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Rarely, DLBCL appears on a background of T-cell and histiocyte-rich stroma, referred to as T-cell/histiocyte rich large B cell lymphoma (T/HRBCL). It is distinguished by its aggressive clinical course and high rates of extranodal malignancy. It is a difficult diagnosis to make.We present a case of a 55-year-old male who presented with an upper gastrointestinal bleed and septic shock. CT imaging of the abdomen revealed a mass arising from the fundus of the stomach infiltrating the spleen. He underwent an exploratory laparotomy, splenectomy, gastric wedge resection of the fundus, and a distal pancreatectomy, with pathological specimens revealing T-cell rich B cell lymphoma. He is being treated with R-CHOP therapy. This case illustrates the importance of understanding the clinical presentations, immunohistochemical analysis, and the diagnostic and therapeutic challenges of a patient with T-cell/histiocyte rich large B cell lymphoma. |
| first_indexed | 2024-12-17T13:01:34Z |
| format | Article |
| id | doaj.art-9759c0746d8345adae0cfbeeeae1dba3 |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-12-17T13:01:34Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-9759c0746d8345adae0cfbeeeae1dba32022-12-21T21:47:20ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192020-12-012100041T cell/histiocyte rich B-cell lymphoma: A difficult diagnosis to makeOlutayo A. Sogunro0Rachael Steinhauer1Eugene Lewis2Department of Surgery, Hartford HealthCare, St. Vincent's Medical Center, Bridgeport, CT, United StatesDepartment of Education, Netter School of Medicine Quinnipiac University, North Haven, CT, United States; Corresponding author.Department of Pathology, Hartford HealthCare, St. Vincent's Medical Center, Bridgeport, CT, United StatesDiffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Rarely, DLBCL appears on a background of T-cell and histiocyte-rich stroma, referred to as T-cell/histiocyte rich large B cell lymphoma (T/HRBCL). It is distinguished by its aggressive clinical course and high rates of extranodal malignancy. It is a difficult diagnosis to make.We present a case of a 55-year-old male who presented with an upper gastrointestinal bleed and septic shock. CT imaging of the abdomen revealed a mass arising from the fundus of the stomach infiltrating the spleen. He underwent an exploratory laparotomy, splenectomy, gastric wedge resection of the fundus, and a distal pancreatectomy, with pathological specimens revealing T-cell rich B cell lymphoma. He is being treated with R-CHOP therapy. This case illustrates the importance of understanding the clinical presentations, immunohistochemical analysis, and the diagnostic and therapeutic challenges of a patient with T-cell/histiocyte rich large B cell lymphoma.http://www.sciencedirect.com/science/article/pii/S2666621920300417T-cell rich B-cell lymphomaLarge B-cell lymphomaR-CHOP therapy |
| spellingShingle | Olutayo A. Sogunro Rachael Steinhauer Eugene Lewis T cell/histiocyte rich B-cell lymphoma: A difficult diagnosis to make Current Problems in Cancer: Case Reports T-cell rich B-cell lymphoma Large B-cell lymphoma R-CHOP therapy |
| title | T cell/histiocyte rich B-cell lymphoma: A difficult diagnosis to make |
| title_full | T cell/histiocyte rich B-cell lymphoma: A difficult diagnosis to make |
| title_fullStr | T cell/histiocyte rich B-cell lymphoma: A difficult diagnosis to make |
| title_full_unstemmed | T cell/histiocyte rich B-cell lymphoma: A difficult diagnosis to make |
| title_short | T cell/histiocyte rich B-cell lymphoma: A difficult diagnosis to make |
| title_sort | t cell histiocyte rich b cell lymphoma a difficult diagnosis to make |
| topic | T-cell rich B-cell lymphoma Large B-cell lymphoma R-CHOP therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2666621920300417 |
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