The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis
BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is widely used to treat Alzheimer’s Disease. However, the effect of rTMS is still controversial. The purpose of the present study is to evaluate the effectiveness of rTMS on cognitive performance of AD patients.MethodsWe systematically se...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.980998/full |
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| author | Zhenyu Wei Jiaqi Fu Huazheng Liang Huazheng Liang Mingli Liu Xiaofei Ye Ping Zhong Ping Zhong |
| author_facet | Zhenyu Wei Jiaqi Fu Huazheng Liang Huazheng Liang Mingli Liu Xiaofei Ye Ping Zhong Ping Zhong |
| author_sort | Zhenyu Wei |
| collection | DOAJ |
| description | BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is widely used to treat Alzheimer’s Disease. However, the effect of rTMS is still controversial. The purpose of the present study is to evaluate the effectiveness of rTMS on cognitive performance of AD patients.MethodsWe systematically searched relevant literatures in four major databases - PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials [Central] before 28th April 2022. Both randomized controlled trials and cross-section studies that compared the therapeutic effect of rTMS with blank control or sham stimuli were included.ResultsA total of 14 studies involving 513 AD patients were finally included for meta-analysis. It was found that rTMS significantly improved global cognitive function (SMD = 0.24, 95%CI, 0.12 to 0.36, P = 0.0001) and daily living ability (IADL: SMD = 0.64, 95%CI, 0.21to 1.08, P = 0.004) in patients with AD, but did not show improvement in language, memory, executive ability, and mood. In further analyses, rTMS at 10 Hz, on a single target with 20 sessions of treatment was shown to produce a positive effect. In addition, improvement in cognitive functions lasted for at least 6 weeks (SMD = 0.67, 95%CI, 0.05 to 1.30,P = 0.04).ConclusionrTMS can improve the global cognition and daily living ability of AD patients. In addition, attention should be paid to the safety of rTMS in AD patients with seizures. Given the relatively small sample size, our results should be interpreted with caution. |
| first_indexed | 2024-04-12T18:35:00Z |
| format | Article |
| id | doaj.art-975a24c96a82460fae2a36dbe6936ab5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T18:35:00Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-975a24c96a82460fae2a36dbe6936ab52022-12-22T03:20:58ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-09-011410.3389/fnagi.2022.980998980998The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysisZhenyu Wei0Jiaqi Fu1Huazheng Liang2Huazheng Liang3Mingli Liu4Xiaofei Ye5Ping Zhong6Ping Zhong7Department of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Health Science and Engineering, Shanghai University of Science and Technology, Shanghai, ChinaClinical Research Center for Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Statistics, Naval Medical University, Shanghai, ChinaDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Health Science and Engineering, Shanghai University of Science and Technology, Shanghai, ChinaBackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is widely used to treat Alzheimer’s Disease. However, the effect of rTMS is still controversial. The purpose of the present study is to evaluate the effectiveness of rTMS on cognitive performance of AD patients.MethodsWe systematically searched relevant literatures in four major databases - PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials [Central] before 28th April 2022. Both randomized controlled trials and cross-section studies that compared the therapeutic effect of rTMS with blank control or sham stimuli were included.ResultsA total of 14 studies involving 513 AD patients were finally included for meta-analysis. It was found that rTMS significantly improved global cognitive function (SMD = 0.24, 95%CI, 0.12 to 0.36, P = 0.0001) and daily living ability (IADL: SMD = 0.64, 95%CI, 0.21to 1.08, P = 0.004) in patients with AD, but did not show improvement in language, memory, executive ability, and mood. In further analyses, rTMS at 10 Hz, on a single target with 20 sessions of treatment was shown to produce a positive effect. In addition, improvement in cognitive functions lasted for at least 6 weeks (SMD = 0.67, 95%CI, 0.05 to 1.30,P = 0.04).ConclusionrTMS can improve the global cognition and daily living ability of AD patients. In addition, attention should be paid to the safety of rTMS in AD patients with seizures. Given the relatively small sample size, our results should be interpreted with caution.https://www.frontiersin.org/articles/10.3389/fnagi.2022.980998/fullrepetitive transcranial magnetic stimulationAlzheimer’s diseasecognitive functionactivities of daily livingtherapeutic efficacy |
| spellingShingle | Zhenyu Wei Jiaqi Fu Huazheng Liang Huazheng Liang Mingli Liu Xiaofei Ye Ping Zhong Ping Zhong The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis Frontiers in Aging Neuroscience repetitive transcranial magnetic stimulation Alzheimer’s disease cognitive function activities of daily living therapeutic efficacy |
| title | The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis |
| title_full | The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis |
| title_fullStr | The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis |
| title_full_unstemmed | The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis |
| title_short | The therapeutic efficacy of transcranial magnetic stimulation in managing Alzheimer’s disease: A systemic review and meta-analysis |
| title_sort | therapeutic efficacy of transcranial magnetic stimulation in managing alzheimer s disease a systemic review and meta analysis |
| topic | repetitive transcranial magnetic stimulation Alzheimer’s disease cognitive function activities of daily living therapeutic efficacy |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.980998/full |
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