TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Diabetes mellitus remains one of the most pressing problems in the 21st century. The research objective was to study the level of glycotoxins and oxidation-reduction potential of a serum/cell at the complicated and uncomplicated course of diabetes mellitus type 2 was and find the ways to correct the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2017-11-01
|
| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/491 |
| _version_ | 1797237349586829312 |
|---|---|
| author | N. A. Shemyakina E. V. Namokonov M. A. Darenskaya |
| author_facet | N. A. Shemyakina E. V. Namokonov M. A. Darenskaya |
| author_sort | N. A. Shemyakina |
| collection | DOAJ |
| description | Diabetes mellitus remains one of the most pressing problems in the 21st century. The research objective was to study the level of glycotoxins and oxidation-reduction potential of a serum/cell at the complicated and uncomplicated course of diabetes mellitus type 2 was and find the ways to correct the disorder. Materials and methods. There were three groups of patients aged from 55 up to 70 years, a total of 80 people. The main group (group No. 3) was presented by 40 men suffering from a diabetes mellitus type 2 with a macrovascular disease of the lower extremities. Depending on the chosen remedy and the carried-out therapy, patients of the first group were sectioned into subgroups on 20 people, in the 2nd subgroup additionally N-acetylcysteine solution was introduced in a daily dose of 600 mg once, intravenously, within 7 days. Definition of the studied indicators was made by HPLS methods, prior to therapy, for the third and seventh day. Results. Obtained data confirm activation of polyol pathway of glucose disintegration. Antioxidant potential of the serum and cells decreases. Using N-acetylcysteini in complex therapy reduces implications of carbonyl and oxidative stresses, due to multiple decrease of the final products of glycation. Conclusions. When identifying the presented indicators in patients with diabetic macroangiopathy of the lower extremities, the administration of N-acetylcysteine, intravenously in a daily dose of 600 mg (7 days course) is recommended. |
| first_indexed | 2024-03-08T12:18:09Z |
| format | Article |
| id | doaj.art-975c2325529a48d7b18ada06a3f5f2e0 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:18:20Z |
| publishDate | 2017-11-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-975c2325529a48d7b18ada06a3f5f2e02024-03-28T07:49:19ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962017-11-012616717110.12737/article_5a0a8ee3048e76.65175111491TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUSN. A. Shemyakina0E. V. Namokonov1M. A. Darenskaya2ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава РоссииФГБОУ ВО «Читинская государственная медицинская академия» Минздрава РоссииФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»Diabetes mellitus remains one of the most pressing problems in the 21st century. The research objective was to study the level of glycotoxins and oxidation-reduction potential of a serum/cell at the complicated and uncomplicated course of diabetes mellitus type 2 was and find the ways to correct the disorder. Materials and methods. There were three groups of patients aged from 55 up to 70 years, a total of 80 people. The main group (group No. 3) was presented by 40 men suffering from a diabetes mellitus type 2 with a macrovascular disease of the lower extremities. Depending on the chosen remedy and the carried-out therapy, patients of the first group were sectioned into subgroups on 20 people, in the 2nd subgroup additionally N-acetylcysteine solution was introduced in a daily dose of 600 mg once, intravenously, within 7 days. Definition of the studied indicators was made by HPLS methods, prior to therapy, for the third and seventh day. Results. Obtained data confirm activation of polyol pathway of glucose disintegration. Antioxidant potential of the serum and cells decreases. Using N-acetylcysteini in complex therapy reduces implications of carbonyl and oxidative stresses, due to multiple decrease of the final products of glycation. Conclusions. When identifying the presented indicators in patients with diabetic macroangiopathy of the lower extremities, the administration of N-acetylcysteine, intravenously in a daily dose of 600 mg (7 days course) is recommended.https://www.actabiomedica.ru/jour/article/view/491glyoxalmethylglyoxalmalondialdehydediabetescomplications of diabetescysteineglutathioneantioxidant system |
| spellingShingle | N. A. Shemyakina E. V. Namokonov M. A. Darenskaya TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Acta Biomedica Scientifica glyoxal methylglyoxal malondialdehyde diabetes complications of diabetes cysteine glutathione antioxidant system |
| title | TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_full | TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_fullStr | TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_full_unstemmed | TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_short | TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| title_sort | to the question of diagnostics and ways of correction of the diabetic macrovascular disease of the lower extremities in patients with type 2 diabetes mellitus |
| topic | glyoxal methylglyoxal malondialdehyde diabetes complications of diabetes cysteine glutathione antioxidant system |
| url | https://www.actabiomedica.ru/jour/article/view/491 |
| work_keys_str_mv | AT nashemyakina tothequestionofdiagnosticsandwaysofcorrectionofthediabeticmacrovasculardiseaseofthelowerextremitiesinpatientswithtype2diabetesmellitus AT evnamokonov tothequestionofdiagnosticsandwaysofcorrectionofthediabeticmacrovasculardiseaseofthelowerextremitiesinpatientswithtype2diabetesmellitus AT madarenskaya tothequestionofdiagnosticsandwaysofcorrectionofthediabeticmacrovasculardiseaseofthelowerextremitiesinpatientswithtype2diabetesmellitus |