Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer Patients

Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer Patients

Oxidative stress with subsequent premutagenic oxidative DNA damage has been implicated in colorectal carcinogenesis. The repair of oxidative DNA damage is initiated by lesion-specific DNA glycosylases (hOGG1, NTH1, MUTYH). The direct evidence of the role of oxidative DNA damage and its repair is pro...

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Bibliographic Details
Main Authors: Pavel Vodicka, Marketa Urbanova, Pavol Makovicky, Kristyna Tomasova, Michal Kroupa, Rudolf Stetina, Alena Opattova, Klara Kostovcikova, Anna Siskova, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative DNA damage
DNA repair
base excision repair (BER)glycosylases
colorectal cancer
Online Access:https://www.mdpi.com/1422-0067/21/7/2473

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