In vivo Neutralization of Naturally Existing Antibodies against Linear ?(1,3)-Galactosidic Carbohydrate Epitopes by Multivalent Antigen Presentation: A Solution for the First Hurdle of Pig-to-Human Xenotransplantation

In vivo Neutralization of Naturally Existing Antibodies against Linear ?(1,3)-Galactosidic Carbohydrate Epitopes by Multivalent Antigen Presentation: A Solution for the First Hurdle of Pig-to-Human Xenotransplantation

Pig-to-human xenotransplantation of islet cells or of vascularized organs would offer a welcome treatment alternative for the ever-increasing number of patients with end-stage organ failure who are waiting for a suitable allograph. The main hurdle are preexisting antibodies, most of which...

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Bibliographic Details
Main Authors: Rudolf O. Duthaler, Beat Ernst, Reto Fischer, Andreas G. Katopodis, Willy Kinzy, Wolfgang Marterer, Reinhold Oehrlein, Markus B. Streiff, Gebhard Thoma
Format: Article
Language:deu
Published: Swiss Chemical Society 2010-02-01
Series:CHIMIA
Subjects:
Carbohydrate antigens
Enzymatic glycosylation
Gas914
Glycopolymer
Xenotransplantation
Online Access:https://www.chimia.ch/chimia/article/view/4792

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