Neonatal Colonic Inflammation Increases Spinal Transmission and Cystathionine β-Synthetase Expression in Spinal Dorsal Horn of Rats with Visceral Hypersensitivity

Neonatal Colonic Inflammation Increases Spinal Transmission and Cystathionine β-Synthetase Expression in Spinal Dorsal Horn of Rats with Visceral Hypersensitivity

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and alteration of bowel movements. The pathogenesis of visceral hypersensitivity in IBS patients remains largely unknown. Hydrogen sulfide (H2S) is reported to play an important role in devel...

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Bibliographic Details
Main Authors: Liting Zhao, Ying Xiao, Rui-Xia Weng, Xuelian Liu, Ping-An Zhang, Chuang-Ying Hu, Shan P. Yu, Guang-Yin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
hydrogen sulfide
visceral pain
spinal cord dorsal horn
excitatory post-synaptic current
irritable bowel syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00696/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00696/full

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