Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators

Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators

Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a distinguishing feature in several neurodegene...

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Bibliographic Details
Main Authors: Rupesh Kumar, Thirumurthy Madhavan, Kalaiarasan Ponnusamy, Honglae Sohn, Shazia Haider
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Genetics
Subjects:
neurodegenerative diseases
amyotrophic lateral sclerosis
kinesin family member 5A
nonsynonymous single-nucleotide polymorphisms
protein‐protein interaction
phytochemicals
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1282234/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1282234/full

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