Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik
Background . The shift away from traditional lifestyle in the Inuit population over the past few decades has been associated with an increased prevalence of coronary heart disease (CHD) risk factors such as obesity, high blood pressure (BP) and diabetes. However, the impact of this transition on the...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2012-10-01
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| Series: | International Journal of Circumpolar Health |
| Subjects: | |
| Online Access: | http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/19066/pdf_1 |
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| author | Marie-Eve Labonté Eric Dewailly Marie-Ludivine Chateau-Degat Patrick Couture Benoît Lamarche |
| author_facet | Marie-Eve Labonté Eric Dewailly Marie-Ludivine Chateau-Degat Patrick Couture Benoît Lamarche |
| author_sort | Marie-Eve Labonté |
| collection | DOAJ |
| description | Background . The shift away from traditional lifestyle in the Inuit population over the past few decades has been associated with an increased prevalence of coronary heart disease (CHD) risk factors such as obesity, high blood pressure (BP) and diabetes. However, the impact of this transition on the pro-inflammatory marker high-sensitivity C-reactive protein (hs-CRP) has not been documented. Objectives . To examine the prevalence of elevated plasma hs-CRP concentrations in Inuit from Nunavik in the province of Quebec (Canada) and identify anthropometric, biochemical and lifestyle risk factors associated with elevated hs-CRP. Design . A population-representative sample of 801 Inuit residents from 14 villages of Nunavik, aged between 18 and 74 years, was included in the analyses. Subjects participated in a clinical session and completed questionnaires on lifestyle. Multivariate logistic regression was used to determine risk factors for elevated hs-CRP. Results . Elevated plasma hs-CRP concentrations (≥2 mg/L) were present in 32.7% (95% confidence interval (CI) 29.5–35.8) of the Inuit adult population and were more prevalent among women than among men (36.7% vs. 29.0%, p=0.007). Multivariate logistic regression analysis indicated that every 1 mmHg increase in systolic BP was associated with a 3% increase in the odds of having hs-CRP concentrations ≥2 mg/L in the Inuit population (95% CI 1.01–1.04). The combination of older age (≥50 vs. <30 years) and elevated waist circumference (gender-specific cut-off values) in a multivariate logistic model was also associated with a 13.3-fold increase in the odds of having plasma hs-CRP concentrations ≥2 mg/L (95% CI 5.8–30.9). Conclusions . These data indicate that elevated hs-CRP is relatively prevalent among Inuit with values that are similar to those seen in Canadian Caucasian populations. Sex, age, waist circumference and systolic BP are major factors that increase the risk of this inflammatory phenotype among Inuit from Nunavik, despite their different lifestyle background compared with Caucasians. |
| first_indexed | 2024-12-23T06:47:25Z |
| format | Article |
| id | doaj.art-9767216c8d1e4e93bbfd04d39b44bc3f |
| institution | Directory Open Access Journal |
| issn | 2242-3982 |
| language | English |
| last_indexed | 2024-12-23T06:47:25Z |
| publishDate | 2012-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Circumpolar Health |
| spelling | doaj.art-9767216c8d1e4e93bbfd04d39b44bc3f2022-12-21T17:56:33ZengTaylor & Francis GroupInternational Journal of Circumpolar Health2242-39822012-10-017101910.3402/ijch.v71i0.19066Population-based study of high plasma C-reactive protein concentrations among the Inuit of NunavikMarie-Eve LabontéEric DewaillyMarie-Ludivine Chateau-DegatPatrick CoutureBenoît LamarcheBackground . The shift away from traditional lifestyle in the Inuit population over the past few decades has been associated with an increased prevalence of coronary heart disease (CHD) risk factors such as obesity, high blood pressure (BP) and diabetes. However, the impact of this transition on the pro-inflammatory marker high-sensitivity C-reactive protein (hs-CRP) has not been documented. Objectives . To examine the prevalence of elevated plasma hs-CRP concentrations in Inuit from Nunavik in the province of Quebec (Canada) and identify anthropometric, biochemical and lifestyle risk factors associated with elevated hs-CRP. Design . A population-representative sample of 801 Inuit residents from 14 villages of Nunavik, aged between 18 and 74 years, was included in the analyses. Subjects participated in a clinical session and completed questionnaires on lifestyle. Multivariate logistic regression was used to determine risk factors for elevated hs-CRP. Results . Elevated plasma hs-CRP concentrations (≥2 mg/L) were present in 32.7% (95% confidence interval (CI) 29.5–35.8) of the Inuit adult population and were more prevalent among women than among men (36.7% vs. 29.0%, p=0.007). Multivariate logistic regression analysis indicated that every 1 mmHg increase in systolic BP was associated with a 3% increase in the odds of having hs-CRP concentrations ≥2 mg/L in the Inuit population (95% CI 1.01–1.04). The combination of older age (≥50 vs. <30 years) and elevated waist circumference (gender-specific cut-off values) in a multivariate logistic model was also associated with a 13.3-fold increase in the odds of having plasma hs-CRP concentrations ≥2 mg/L (95% CI 5.8–30.9). Conclusions . These data indicate that elevated hs-CRP is relatively prevalent among Inuit with values that are similar to those seen in Canadian Caucasian populations. Sex, age, waist circumference and systolic BP are major factors that increase the risk of this inflammatory phenotype among Inuit from Nunavik, despite their different lifestyle background compared with Caucasians.http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/19066/pdf_1Nunavikrisk factorswaist circumferenceagingsexsystolic blood pressureInuitC-reactive proteinprevalence |
| spellingShingle | Marie-Eve Labonté Eric Dewailly Marie-Ludivine Chateau-Degat Patrick Couture Benoît Lamarche Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik International Journal of Circumpolar Health Nunavik risk factors waist circumference aging sex systolic blood pressure Inuit C-reactive protein prevalence |
| title | Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik |
| title_full | Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik |
| title_fullStr | Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik |
| title_full_unstemmed | Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik |
| title_short | Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik |
| title_sort | population based study of high plasma c reactive protein concentrations among the inuit of nunavik |
| topic | Nunavik risk factors waist circumference aging sex systolic blood pressure Inuit C-reactive protein prevalence |
| url | http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/19066/pdf_1 |
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