Cell-Penetrating Peptides and Transportan
In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostal...
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| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
MDPI AG
2021-06-01
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| シリーズ: | Pharmaceutics |
| 主題: | |
| オンライン･アクセス: | https://www.mdpi.com/1999-4923/13/7/987 |
| _version_ | 1827600864512049152 |
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| author | Ülo Langel |
| author_facet | Ülo Langel |
| author_sort | Ülo Langel |
| collection | DOAJ |
| description | In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostalgic journey into the research in my own laboratories, which lead to multiple CPPs, starting from transportan and paving a way to CPP-based therapeutic developments in the delivery of bio-functional materials, such as peptides, proteins, vaccines, oligonucleotides and small molecules, etc. |
| first_indexed | 2024-03-09T04:44:08Z |
| format | Article |
| id | doaj.art-9768a20455384523873e3d3832c8358a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T04:44:08Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9768a20455384523873e3d3832c8358a2023-12-03T13:17:53ZengMDPI AGPharmaceutics1999-49232021-06-0113798710.3390/pharmaceutics13070987Cell-Penetrating Peptides and TransportanÜlo Langel0Department of Biochemistry and Biophysics, Stockholm University, S.Arrheniusv. 16B, Room C466, SE-106 91 Stockholm, SwedenIn the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostalgic journey into the research in my own laboratories, which lead to multiple CPPs, starting from transportan and paving a way to CPP-based therapeutic developments in the delivery of bio-functional materials, such as peptides, proteins, vaccines, oligonucleotides and small molecules, etc.https://www.mdpi.com/1999-4923/13/7/987transportancell-penetrating peptidestransfectionPepFectNickFect |
| spellingShingle | Ülo Langel Cell-Penetrating Peptides and Transportan Pharmaceutics transportan cell-penetrating peptides transfection PepFect NickFect |
| title | Cell-Penetrating Peptides and Transportan |
| title_full | Cell-Penetrating Peptides and Transportan |
| title_fullStr | Cell-Penetrating Peptides and Transportan |
| title_full_unstemmed | Cell-Penetrating Peptides and Transportan |
| title_short | Cell-Penetrating Peptides and Transportan |
| title_sort | cell penetrating peptides and transportan |
| topic | transportan cell-penetrating peptides transfection PepFect NickFect |
| url | https://www.mdpi.com/1999-4923/13/7/987 |
| work_keys_str_mv | AT ulolangel cellpenetratingpeptidesandtransportan |