Apical Medium Flow Influences the Morphology and Physiology of Human Proximal Tubular Cells in a Microphysiological System

Apical Medium Flow Influences the Morphology and Physiology of Human Proximal Tubular Cells in a Microphysiological System

There is a lack of physiologically relevant in vitro human kidney models for disease modelling and detecting drug-induced effects given the limited choice of cells and difficulty implementing quasi-physiological culture conditions. We investigated the influence of fluid shear stress on primary human...

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Bibliographic Details
Main Authors: Gabriele Specioso, David Bovard, Filippo Zanetti, Fabio Maranzano, Céline Merg, Antonin Sandoz, Bjoern Titz, Federico Dalcanale, Julia Hoeng, Kasper Renggli, Laura Suter-Dick
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Bioengineering
Subjects:
microfluidics
organ-on-chip
micro-physiological systems
cilia
kidney
Online Access:https://www.mdpi.com/2306-5354/9/10/516

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