The health status of Q-fever patients after long-term follow-up
<p>Abstract</p> <p>Background</p> <p>In the Netherlands, from 2007 to 2009, 3,522 Q-fever cases were notified from three outbreaks. These are the largest documented outbreaks in the world. Previous studies suggest that symptoms can persist for a long period of time, res...
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| Format: | Article |
| Language: | English |
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BMC
2011-04-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://www.biomedcentral.com/1471-2334/11/97 |
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| author | Hautvast Jeannine LA Bor Hans HJ van Nieuwenhof Malou Peters Jeannette B Morroy Gabriëlla van der Hoek Wim Wijkmans Clementine J Vercoulen Jan H |
| author_facet | Hautvast Jeannine LA Bor Hans HJ van Nieuwenhof Malou Peters Jeannette B Morroy Gabriëlla van der Hoek Wim Wijkmans Clementine J Vercoulen Jan H |
| author_sort | Hautvast Jeannine LA |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In the Netherlands, from 2007 to 2009, 3,522 Q-fever cases were notified from three outbreaks. These are the largest documented outbreaks in the world. Previous studies suggest that symptoms can persist for a long period of time, resulting in a reduced quality of life (QoL). The aim of this study was to qualify and quantify the health status of Q-fever patients after long-term follow-up.</p> <p>Methods</p> <p>870 Q-fever patients of the 2007 and 2008 outbreaks were mailed a questionnaire 12 to 26 months after the onset of illness. We assessed demographic data and measured health status with the Nijmegen Clinical Screening Instrument (NCSI). The NCSI consists of three main domains of functional impairment, symptoms and QoL that are divided into eight sub-domains. The NCSI scores of Q-fever patients older than 50 years (N = 277) were compared with patients younger than 50 years (N = 238) and with norm data from healthy individuals (N = 65) and patients with chronic obstructive pulmonary disease (N = 128).</p> <p>Results</p> <p>The response rate was 65.7%. After applying exclusion criteria 515 Q-fever patients were included in this study. The long-term health status of two thirds of Q-fever patients (both younger and older than 50 years) was severely affected for at least one sub-domain. Patients scores were most severely affected on the sub-domains general QoL (44.9%) and fatigue (43.5%). Hospitalisation in the acute phase was significantly related to long-term behavioural impairment (OR 2.8, CI 1.5-5.1), poor health related QoL (OR 2.3,CI 1.5-4.0) and subjective symptoms (OR 1.9, CI 1.1-3.6). Lung or heart disease, depression and arthritis significantly affected the long-term health status of Q-fever patients.</p> <p>Conclusions</p> <p>Q-fever patients presented 12 to 26 months after the onset of illness severe -clinically relevant- subjective symptoms, functional impairment and impaired QoL. All measured sub-domains of the health status were impaired. Hospitalisation and co-morbidity were predictors for worse scores. Our data emphasise that more attention is needed not only to prevent exposure to Q-fever but also for the prevention and treatment of the long-term consequences of this zoönosis.</p> |
| first_indexed | 2024-12-19T09:07:08Z |
| format | Article |
| id | doaj.art-9769681f1d4d4e7a9a5af57d4e1750bd |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-19T09:07:08Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj.art-9769681f1d4d4e7a9a5af57d4e1750bd2022-12-21T20:28:19ZengBMCBMC Infectious Diseases1471-23342011-04-011119710.1186/1471-2334-11-97The health status of Q-fever patients after long-term follow-upHautvast Jeannine LABor Hans HJvan Nieuwenhof MalouPeters Jeannette BMorroy Gabriëllavan der Hoek WimWijkmans Clementine JVercoulen Jan H<p>Abstract</p> <p>Background</p> <p>In the Netherlands, from 2007 to 2009, 3,522 Q-fever cases were notified from three outbreaks. These are the largest documented outbreaks in the world. Previous studies suggest that symptoms can persist for a long period of time, resulting in a reduced quality of life (QoL). The aim of this study was to qualify and quantify the health status of Q-fever patients after long-term follow-up.</p> <p>Methods</p> <p>870 Q-fever patients of the 2007 and 2008 outbreaks were mailed a questionnaire 12 to 26 months after the onset of illness. We assessed demographic data and measured health status with the Nijmegen Clinical Screening Instrument (NCSI). The NCSI consists of three main domains of functional impairment, symptoms and QoL that are divided into eight sub-domains. The NCSI scores of Q-fever patients older than 50 years (N = 277) were compared with patients younger than 50 years (N = 238) and with norm data from healthy individuals (N = 65) and patients with chronic obstructive pulmonary disease (N = 128).</p> <p>Results</p> <p>The response rate was 65.7%. After applying exclusion criteria 515 Q-fever patients were included in this study. The long-term health status of two thirds of Q-fever patients (both younger and older than 50 years) was severely affected for at least one sub-domain. Patients scores were most severely affected on the sub-domains general QoL (44.9%) and fatigue (43.5%). Hospitalisation in the acute phase was significantly related to long-term behavioural impairment (OR 2.8, CI 1.5-5.1), poor health related QoL (OR 2.3,CI 1.5-4.0) and subjective symptoms (OR 1.9, CI 1.1-3.6). Lung or heart disease, depression and arthritis significantly affected the long-term health status of Q-fever patients.</p> <p>Conclusions</p> <p>Q-fever patients presented 12 to 26 months after the onset of illness severe -clinically relevant- subjective symptoms, functional impairment and impaired QoL. All measured sub-domains of the health status were impaired. Hospitalisation and co-morbidity were predictors for worse scores. Our data emphasise that more attention is needed not only to prevent exposure to Q-fever but also for the prevention and treatment of the long-term consequences of this zoönosis.</p>http://www.biomedcentral.com/1471-2334/11/97Q-feverCoxiella burnetiicohortintegral health statusquality of life |
| spellingShingle | Hautvast Jeannine LA Bor Hans HJ van Nieuwenhof Malou Peters Jeannette B Morroy Gabriëlla van der Hoek Wim Wijkmans Clementine J Vercoulen Jan H The health status of Q-fever patients after long-term follow-up BMC Infectious Diseases Q-fever Coxiella burnetii cohort integral health status quality of life |
| title | The health status of Q-fever patients after long-term follow-up |
| title_full | The health status of Q-fever patients after long-term follow-up |
| title_fullStr | The health status of Q-fever patients after long-term follow-up |
| title_full_unstemmed | The health status of Q-fever patients after long-term follow-up |
| title_short | The health status of Q-fever patients after long-term follow-up |
| title_sort | health status of q fever patients after long term follow up |
| topic | Q-fever Coxiella burnetii cohort integral health status quality of life |
| url | http://www.biomedcentral.com/1471-2334/11/97 |
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