A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma
Canine oral melanoma (COM) is a highly aggressive tumour associated with poor prognosis due to metastasis and resistance to conventional anti-cancer therapies. As with human mucosal melanoma, the mutational landscape is predominated by copy number aberrations and chromosomal structural variants, but...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/8/11/286 |
| _version_ | 1797508217169772544 |
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| author | Laura Hardwick |
| author_facet | Laura Hardwick |
| author_sort | Laura Hardwick |
| collection | DOAJ |
| description | Canine oral melanoma (COM) is a highly aggressive tumour associated with poor prognosis due to metastasis and resistance to conventional anti-cancer therapies. As with human mucosal melanoma, the mutational landscape is predominated by copy number aberrations and chromosomal structural variants, but differences in study cohorts and/or tumour heterogeneity can lead to discordant results regarding the nature of specific genes affected. This review discusses somatic molecular alterations in COM that result from single nucleotide variations, copy number changes, chromosomal rearrangements, and/or dysregulation of small non-coding RNAs. A cross-species comparison highlights notable recurrent aberrations, and functionally grouping dysregulated proteins reveals unifying biological pathways that may be critical for oncogenesis and metastasis. Finally, potential therapeutic strategies are considered to target these pathways in canine patients, and the benefits of collaboration between science, medical, and veterinary communities are emphasised. |
| first_indexed | 2024-03-10T04:59:21Z |
| format | Article |
| id | doaj.art-976bf3f7af064a1a80c96dff4119402e |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T04:59:21Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-976bf3f7af064a1a80c96dff4119402e2023-11-23T01:54:52ZengMDPI AGVeterinary Sciences2306-73812021-11-0181128610.3390/vetsci8110286A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral MelanomaLaura Hardwick0Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UKCanine oral melanoma (COM) is a highly aggressive tumour associated with poor prognosis due to metastasis and resistance to conventional anti-cancer therapies. As with human mucosal melanoma, the mutational landscape is predominated by copy number aberrations and chromosomal structural variants, but differences in study cohorts and/or tumour heterogeneity can lead to discordant results regarding the nature of specific genes affected. This review discusses somatic molecular alterations in COM that result from single nucleotide variations, copy number changes, chromosomal rearrangements, and/or dysregulation of small non-coding RNAs. A cross-species comparison highlights notable recurrent aberrations, and functionally grouping dysregulated proteins reveals unifying biological pathways that may be critical for oncogenesis and metastasis. Finally, potential therapeutic strategies are considered to target these pathways in canine patients, and the benefits of collaboration between science, medical, and veterinary communities are emphasised.https://www.mdpi.com/2306-7381/8/11/286caninegeneticsmelanomamalignantoralpathogenesis |
| spellingShingle | Laura Hardwick A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma Veterinary Sciences canine genetics melanoma malignant oral pathogenesis |
| title | A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma |
| title_full | A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma |
| title_fullStr | A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma |
| title_full_unstemmed | A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma |
| title_short | A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma |
| title_sort | comparative view on molecular alterations and potential therapeutic strategies for canine oral melanoma |
| topic | canine genetics melanoma malignant oral pathogenesis |
| url | https://www.mdpi.com/2306-7381/8/11/286 |
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