Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

Macropinosome formation requires the sequential activation of numerous signaling pathways that coordinate the actin-driven formation of plasma membrane protrusions (ruffles) and circular ruffles (macropinocytic cups), followed by the closure of these macropinocytic cups into macropinosomes. In the p...

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Bibliographic Details
Main Authors: Youhei eEgami, Tomohiko eTaguchi, Masashi eMaekawa, Hiroyuki eArai, Nobukazu eAraki
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Physiology
Subjects:
phosphoinositides
Rac1
optogenetics
small GTPases
macropinocytosis
Myotubularin-related proteins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00374/full

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