Early versus late extubation after surfactant replacement therapy for respiratory distress syndrome
Patients and methods: Ninety patients treated by surfactant replacement therapy were included in the study. Patients were divided into 2 groups; group A consists of patients who were extubated early within 24 h after surfactant administration and group B consists of patients who were extubated after...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-03-01
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| Series: | Egyptian Pediatric Association Gazette |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S111066381500004X |
| _version_ | 1818041928910897152 |
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| author | Mohamed Garib Niveen Salama Salem Deraz |
| author_facet | Mohamed Garib Niveen Salama Salem Deraz |
| author_sort | Mohamed Garib |
| collection | DOAJ |
| description | Patients and methods: Ninety patients treated by surfactant replacement therapy were included in the study. Patients were divided into 2 groups; group A consists of patients who were extubated early within 24 h after surfactant administration and group B consists of patients who were extubated after 24 h from surfactant administration.
Results: 59 patients were extubated early (within 24 h after surfactant administration) while 31 patients were extubated late (after 24 h from surfactant administration). Patients in group B (late extubation group) had a longer duration of CPAP (41.53 + 9.74 h in group B versus 17.30 + 4.03 h in group A), a longer duration of total oxygen administration (73.41 + 11.24 h in group B versus 45.33 + 5.22 h in group A) and a longer duration of hospital stay (171.88 + 75.74 h in group B versus 106.82 + 52.79 h in group A) than patients in group A (early extubation group). 41 (69.50%) Patients who were extubated early received surfactants at or before the age of 6 h while 22 (70.97%) patients who were extubated late received surfactants after the age of 6 h. Regarding complications, 6 patients had transient bradycardia (6.7%), 4 patients had pneumothorax (4.4%) and 4 patients had pulmonary hemorrhage (4.4%).
Conclusion: Early administration of surfactants is associated with early extubation. Patients who were extubated early (most of them had an early administration of surfactants) had a lower chance for re-intubation, less duration of total oxygen administration and less hospital stay. |
| first_indexed | 2024-12-10T08:38:13Z |
| format | Article |
| id | doaj.art-976ee8ae78504891b97ec3d7641c1f93 |
| institution | Directory Open Access Journal |
| issn | 1110-6638 |
| language | English |
| last_indexed | 2024-12-10T08:38:13Z |
| publishDate | 2015-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Pediatric Association Gazette |
| spelling | doaj.art-976ee8ae78504891b97ec3d7641c1f932022-12-22T01:55:54ZengSpringerOpenEgyptian Pediatric Association Gazette1110-66382015-03-016311510.1016/j.epag.2015.02.003Early versus late extubation after surfactant replacement therapy for respiratory distress syndromeMohamed Garib0Niveen Salama1Salem Deraz2Department of Pediatrics, Menoufia University, EgyptDepartment of Pediatrics, Cairo University, EgyptDepartment of Pediatrics, Menoufia University, EgyptPatients and methods: Ninety patients treated by surfactant replacement therapy were included in the study. Patients were divided into 2 groups; group A consists of patients who were extubated early within 24 h after surfactant administration and group B consists of patients who were extubated after 24 h from surfactant administration. Results: 59 patients were extubated early (within 24 h after surfactant administration) while 31 patients were extubated late (after 24 h from surfactant administration). Patients in group B (late extubation group) had a longer duration of CPAP (41.53 + 9.74 h in group B versus 17.30 + 4.03 h in group A), a longer duration of total oxygen administration (73.41 + 11.24 h in group B versus 45.33 + 5.22 h in group A) and a longer duration of hospital stay (171.88 + 75.74 h in group B versus 106.82 + 52.79 h in group A) than patients in group A (early extubation group). 41 (69.50%) Patients who were extubated early received surfactants at or before the age of 6 h while 22 (70.97%) patients who were extubated late received surfactants after the age of 6 h. Regarding complications, 6 patients had transient bradycardia (6.7%), 4 patients had pneumothorax (4.4%) and 4 patients had pulmonary hemorrhage (4.4%). Conclusion: Early administration of surfactants is associated with early extubation. Patients who were extubated early (most of them had an early administration of surfactants) had a lower chance for re-intubation, less duration of total oxygen administration and less hospital stay.http://www.sciencedirect.com/science/article/pii/S111066381500004XSurfactantExtubationRespiratory distress |
| spellingShingle | Mohamed Garib Niveen Salama Salem Deraz Early versus late extubation after surfactant replacement therapy for respiratory distress syndrome Egyptian Pediatric Association Gazette Surfactant Extubation Respiratory distress |
| title | Early versus late extubation after surfactant replacement therapy for respiratory distress syndrome |
| title_full | Early versus late extubation after surfactant replacement therapy for respiratory distress syndrome |
| title_fullStr | Early versus late extubation after surfactant replacement therapy for respiratory distress syndrome |
| title_full_unstemmed | Early versus late extubation after surfactant replacement therapy for respiratory distress syndrome |
| title_short | Early versus late extubation after surfactant replacement therapy for respiratory distress syndrome |
| title_sort | early versus late extubation after surfactant replacement therapy for respiratory distress syndrome |
| topic | Surfactant Extubation Respiratory distress |
| url | http://www.sciencedirect.com/science/article/pii/S111066381500004X |
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