A Nut for Every Bolt: Subunit-Selective Inhibitors of the Immunoproteasome and Their Therapeutic Potential

A Nut for Every Bolt: Subunit-Selective Inhibitors of the Immunoproteasome and Their Therapeutic Potential

At the heart of the ubiquitin–proteasome system, the 20S proteasome core particle (CP) breaks down the majority of intracellular proteins tagged for destruction. Thereby, the CP controls many cellular processes including cell cycle progression and cell signalling. Inhibitors of the CP can suppress t...

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Bibliographic Details
Main Authors: Eva M. Huber, Michael Groll
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
immunoproteasome
inhibition
inflammation
autoimmune diseases
drug development
Online Access:https://www.mdpi.com/2073-4409/10/8/1929

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